| ŠERÝ, Omar, Olga HRAZDILOVÁ, Věra KLENEROVÁ, Radim ŠTAIF, Vladimír ZNOJIL a Pavel ŠEVČÍK. The association of monoamine oxidase B functional polymorphism with postoperative pain intensity. Neuroendocrinology Letters. Sweden, Stockholm: Maghira and Maas Publications, roč. 27, č. 3, s. 333-337. ISSN 0172-780X. 2006. |
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@article{634024,
author = {Šerý, Omar and Hrazdilová, Olga and Klenerová, Věra and Štaif, Radim and Znojil, Vladimír and Ševčík, Pavel},
article_location = {Sweden, Stockholm},
article_number = {3},
keywords = {association; MAOB; pain; polymorphism; gene},
language = {eng},
issn = {0172-780X},
journal = {Neuroendocrinology Letters},
title = {The association of monoamine oxidase B functional polymorphism with postoperative pain intensity},
volume = {27},
year = {2006}
}
TY - JOUR
ID - 634024
AU - Šerý, Omar - Hrazdilová, Olga - Klenerová, Věra - Štaif, Radim - Znojil, Vladimír - Ševčík, Pavel
PY - 2006
TI - The association of monoamine oxidase B functional polymorphism with postoperative pain intensity
JF - Neuroendocrinology Letters
VL - 27
IS - 3
SP - 333-337
EP - 333-337
PB - Maghira and Maas Publications
SN - 0172780X
KW - association
KW - MAOB
KW - pain
KW - polymorphism
KW - gene
N2 - Objectives: The monoamine oxidase B (MAO-B) is an enzyme involved in metabolism of dopamine, benzylamine, phenylethylamine, tyramine and tryptamine. The A/G polymorphism in intron 13 of the MAO-B gene has been previously found to be associated with variability of the MAO-B enzyme activity. The aim of the present association study has been to examine the relationship between the A/G polymorphism in intron 13 and postoperative pain intensity. Methods: 284 subjects (105 males and 179 females) undergoing planned tonsillectomy were examined. The intensity of pain was evaluated using 100-mm visual analogue scale (VAS). A PCR method with allele specific primers for detection of A/G polymorphism was used. Results: We found a relationship between the A/G polymorphism in intron 13 of the MAO-B gene and average intensity of postoperative pain in male subjects. Higher average intensity of postoperative pain was detected in males with the G allele (3.96) in comparison with males with the A allele (3.45) and the difference was statistically significant (p<0,03). Conclusions: Results of this study indicate the relationship between the MAO-B polymorphism and postoperative pain intensity in the Czech male population. A potential role of MAO-B in the perception of pain intensity is discussed.
ER -
ŠERÝ, Omar, Olga HRAZDILOVÁ, Věra KLENEROVÁ, Radim ŠTAIF, Vladimír ZNOJIL a Pavel ŠEVČÍK. The association of monoamine oxidase B functional polymorphism with postoperative pain intensity. \textit{Neuroendocrinology Letters}. Sweden, Stockholm: Maghira and Maas Publications, roč.~27, č.~3, s.~333-337. ISSN~0172-780X. 2006.
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