Detailed Information on Publication Record
2006
The association of monoamine oxidase B functional polymorphism with postoperative pain intensity
ŠERÝ, Omar, Olga HRAZDILOVÁ, Věra KLENEROVÁ, Radim ŠTAIF, Vladimír ZNOJIL et. al.Basic information
Original name
The association of monoamine oxidase B functional polymorphism with postoperative pain intensity
Name in Czech
Vztah funkčního polymorfizmu monoaminooxidázy A k intenzitě pooperační bolesti
Authors
ŠERÝ, Omar (203 Czech Republic, guarantor), Olga HRAZDILOVÁ (203 Czech Republic), Věra KLENEROVÁ (203 Czech Republic), Radim ŠTAIF (203 Czech Republic), Vladimír ZNOJIL (203 Czech Republic) and Pavel ŠEVČÍK (203 Czech Republic)
Edition
Neuroendocrinology Letters, Sweden, Stockholm, Maghira and Maas Publications, 2006, 0172-780X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 0.924
RIV identification code
RIV/00216224:14310/06:00016778
Organization unit
Faculty of Science
UT WoS
000240443500006
Keywords in English
association; MAOB; pain; polymorphism; gene
Tags
Tags
International impact, Reviewed
Změněno: 13/2/2008 17:33, prof. RNDr. Omar Šerý, Ph.D.
V originále
Objectives: The monoamine oxidase B (MAO-B) is an enzyme involved in metabolism of dopamine, benzylamine, phenylethylamine, tyramine and tryptamine. The A/G polymorphism in intron 13 of the MAO-B gene has been previously found to be associated with variability of the MAO-B enzyme activity. The aim of the present association study has been to examine the relationship between the A/G polymorphism in intron 13 and postoperative pain intensity. Methods: 284 subjects (105 males and 179 females) undergoing planned tonsillectomy were examined. The intensity of pain was evaluated using 100-mm visual analogue scale (VAS). A PCR method with allele specific primers for detection of A/G polymorphism was used. Results: We found a relationship between the A/G polymorphism in intron 13 of the MAO-B gene and average intensity of postoperative pain in male subjects. Higher average intensity of postoperative pain was detected in males with the G allele (3.96) in comparison with males with the A allele (3.45) and the difference was statistically significant (p<0,03). Conclusions: Results of this study indicate the relationship between the MAO-B polymorphism and postoperative pain intensity in the Czech male population. A potential role of MAO-B in the perception of pain intensity is discussed.
In Czech
V naší práci jsme objevili signifikantní vztah mezi polymorfizmem genu pro MAO B a mírou pooperační bolesti měřenou dle VAS.
Links
| MSM0021620806, plan (intention) |
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| MSM0021622413, plan (intention) |
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| NM7146, research and development project |
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