An unusual clinical appearance and course of pyoderma gangraenosum (PG) in a 35-year-old woman is presented. Sings of both the ulcerative and vegetative forms of PG were expressed. The association of two systemic diseases, the autoimmune thyreopathy and the hyperandrogenic syndrome were observed in a female. The recommended conventional therapy for PG: corticosteroids, antibiotics, cyclosporine and cyclophospamide yielded