Relationship between circulating levels of soluble RAGE (sRAGE) and genetic variability in the AGER gene in subjects with diabetic nephropathy

KAŇKOVÁ, Kateřina, Marta KALOUSOVÁ, Miluše HERTLOVÁ, Darja KRUSOVÁ and Tomáš ZIMA. Relationship between circulating levels of soluble RAGE (sRAGE) and genetic variability in the AGER gene in subjects with diabetic nephropathy. In The Maillard Reaction in Food and Medicine. 2006.

Basic information

• Original name: Relationship between circulating levels of soluble RAGE (sRAGE) and genetic variability in the AGER gene in subjects with diabetic nephropathy
• Name in Czech: Vztah mezi hladinami cirkulujícího solubilního RAGE (sRAGE) a genetickou variabilitou v AGER genu u diabetické nefropatie
• Authors: KAŇKOVÁ, Kateřina (203 Czech Republic, guarantor), Marta KALOUSOVÁ (203 Czech Republic), Miluše HERTLOVÁ (203 Czech Republic), Darja KRUSOVÁ (203 Czech Republic) and Tomáš ZIMA (203 Czech Republic).
• Edition: The Maillard Reaction in Food and Medicine, 2006.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30202 Endocrinology and metabolism
• Country of publisher: Italy
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14330/06:00015337
• Organization unit: Faculty of Informatics
• Keywords in English: diabetic nephropathy; RAGE; polymorphism; sRAGE; renal failure
• Tags: diabetic nephropathy, polymorphism, RAGE, renal failure, sRAGE

Abstract

RAGE2 haplotype was previously identified as a genetic risk factor for the development and early onset of diabetic nephropathy. Curent study showed that (i) sRAGE significantly differed among subjects bearing variable number of RAGE2 haplotype copies, (ii) was significantly higher in subjects with nephropathy than normoalbuminuric patients and (iii) positively correlated with severity of nephropathy, S-urea, S-creatinine and negatively with glomerular filtration rate (GFR). GFR seems to be principal determinant of the AGE and sRAGE levels.

Abstract (in Czech)

RAGE2 haplotyp byl identifikován jako genetický rizikový faktor časného nástupu diabetické nefropatie. Tato studie prokázala, že (i) sRAGE se signifikantně liší mezi skupinami osob nesoucími variabilní počet kopií RAGE2 haplotypu, (ii) sRAGE je signif. vyšší u osob s nefropatií než normoalbuminurických diabetiků a (iii) pozitivně koreluje s tíhou nefropatie, S-ureou, S-kreatininem a negativně s glomerulární filtrační rychlostí (GFR). GFR je zřejmě hlavní determinanta hladin AGE a sRAGE.

Links

• KJB501620601, research and development project: Name: Funkční analýza rizikového haplotypu RAGE genu a jeho role v patogenezi hyperglykemií indukovaných změn

Investor: Academy of Sciences of the Czech Republic, Functional analysis of the RAGE gene susceptibility haplotype and its role in the hyperglycemia-driven pathology

• MSM0021620807, plan (intention): Name: Metabolické, endokrinní a genetické aspekty prevence, diagnostiky a terapie kardiovaskulárních, cerebrovaskulárních a renovaskulárních onemocnění