| JUŘICA, Jan, Josef TOMANDL, Miroslav DOSTÁLEK and Eva HADAŠOVÁ. Determination of midazolam and its metabolites in rat plasma and perfuse medium by HPLC. In CD of the abstracts of the 29th international symposium on capillary chromatography. Belgium: T. Sandra, Research Institute for Chromatography, 2006, p. -, 1 pp. |
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@inproceedings{637052,
author = {Juřica, Jan and Tomandl, Josef and Dostálek, Miroslav and Hadašová, Eva},
address = {Belgium},
booktitle = {CD of the abstracts of the 29th international symposium on capillary chromatography},
keywords = {Cytochrome P450; Midazolam; 1 Hydroxymidazolam; 4 Hydroxymidazolam; 1 4 Dihydroxymidazolam; Rat; Perfuzate; Plasma},
language = {eng},
location = {Belgium},
pages = {-},
publisher = {T. Sandra, Research Institute for Chromatography},
title = {Determination of midazolam and its metabolites in rat plasma and perfuse medium by HPLC},
year = {2006}
}
TY - JOUR
ID - 637052
AU - Juřica, Jan - Tomandl, Josef - Dostálek, Miroslav - Hadašová, Eva
PY - 2006
TI - Determination of midazolam and its metabolites in rat plasma and perfuse medium by HPLC
PB - T. Sandra, Research Institute for Chromatography
CY - Belgium
KW - Cytochrome P450
KW - Midazolam
KW - 1 Hydroxymidazolam
KW - 4 Hydroxymidazolam
KW - 1 4 Dihydroxymidazolam
KW - Rat
KW - Perfuzate
KW - Plasma
N2 - A new isocratic reverse-phase high-performance liquid chromatography utilising ultraviolet detection for the simultaneous determination of midazolam and its three main hydroxymetabolites in rat plasma and rat liver perfuse medium is described. The present method offers various advantages over the currently used HPLC methods, including speed, sensitivity and reproducibility. Moreover, it may be applicable for modelling and description of possible pharmacological interactions on rat or human isoforms of cytochrome P450.
ER -
JUŘICA, Jan, Josef TOMANDL, Miroslav DOSTÁLEK and Eva HADAŠOVÁ. Determination of midazolam and its metabolites in rat plasma and perfuse medium by HPLC. In \textit{CD of the abstracts of the 29th international symposium on capillary chromatography}. Belgium: T. Sandra, Research Institute for Chromatography, 2006, p.~-, 1 pp.
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