EFFECT OF ANTHRACYCLINE THERAPY ON CARDIOVASCULAR REGULATION AND PHYSICAL ACTIVITY

ZÁVODNÁ, Eva, Zuzana NOVÁKOVÁ, Nataša HONZÍKOVÁ, Bohumil FIŠER, Miroslav JÍRA, Jana ŠŤASTNÁ and Hana HRSTKOVÁ. EFFECT OF ANTHRACYCLINE THERAPY ON CARDIOVASCULAR REGULATION AND PHYSICAL ACTIVITY. In 15th Meeting of Paediatric Research of Central European Countries. 2006.

Basic information

• Original name: EFFECT OF ANTHRACYCLINE THERAPY ON CARDIOVASCULAR REGULATION AND PHYSICAL ACTIVITY
• Name in Czech: Vliv léby antracykliny na kardiovaskulární regulaci a fyzickou aktivitu
• Authors: ZÁVODNÁ, Eva (203 Czech Republic, guarantor), Zuzana NOVÁKOVÁ (203 Czech Republic), Nataša HONZÍKOVÁ (203 Czech Republic), Bohumil FIŠER (203 Czech Republic), Miroslav JÍRA (203 Czech Republic), Jana ŠŤASTNÁ (203 Czech Republic) and Hana HRSTKOVÁ (203 Czech Republic).
• Edition: 15th Meeting of Paediatric Research of Central European Countries, 2006.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30105 Physiology
• Country of publisher: Austria
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/06:00016959
• Organization unit: Faculty of Medicine
• Keywords (in Czech): antracykliny; protinádorová léčba; fyzická aktivita; citlivost baroreflexu; děti; adolescenti
• Keywords in English: anthracycline; antitumour therapy; physical activity; baroreflex sensitivity; children; adolescents
• Tags: Adolescents, anthracycline, antitumour therapy, baroreflex sensitivity, children, physical activity
• Tags: International impact, Reviewed

Abstract

We followed effect of anthracycline therapy on physical activity, body and cardiovascular parameters in children treated for malignant tumor. We examined 21 subjects after antitumor therapy (M; 15.5b3.2 years) and 32 healthy subjects (Co; 15.7b2.1 years). In group M, 8 subjects had a non-cardiotoxic therapy (A0), and 13 children were treated with anthracyclines (A+). In group A+ vs. A0 and Co, we found significantly lower SBP. A+ compared with Co had higher BRSf; lower weight and height; lower total physical activity and physical activity related to 1 kg of body weight. In whole group M, we found negative correlation between dose of anthracyclines and SBP and total physical activity. The multiple regression in group M shown that SBP was significantly related to the duration of period without antitumor therapy and to the dosage of anthracyclines. BRSf significantly correlated with body weight, physical activity related to 1 kg of body weight, time since therapy and SBP.

Abstract (in Czech)

Sledovali jsme vliv antracyklinové léčby na fyzickou aktivitu, tělesné a kardiovaskulární parametry u dětí léčených pro maligní nádor. Vyšetili jsme 21 dětí po protinádorové léčbě (M) a 32 zdravých osob (Co). Ve skupin M bylo 8 dětí léčeno nekardiotoxickou léčbou (A0) a 13 dětí bylo léčeno antracykliny (A+). V porovnání ke skupinám A0 a Co, skupina A+měla nižší systolický tlak (STK), vyšší baroreflexní senzitivitu, nižší výšku a hmotnost a fyzickou aktivitu. V celé skupin M s rostoucí dávkou antracykllinů klesal STK a fyzická aktivita.

Links

• MSM0021622402, plan (intention): Name: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases

• NR8006, research and development project: Name: Autonomní oběhové funkce, funkce myokardu a kardiorespirační funkce u dětí a adolescentů po léčbě zhoubného nádoru

Investor: Ministry of Health of the CR