Dynamika psychopatologie u prvních epizod schizofrenie

ČEŠKOVÁ, Eva, Radovan PŘIKRYL, Tomáš KAŠPÁREK and Hana KUČEROVÁ. Dynamika psychopatologie u prvních epizod schizofrenie (Psychopathology and treatment responsiveness of patients with first-episode schizophrenia). In Psychiatria pre prax. Bratislava: Meduca, s. r. o., 2006, p. 21 - 21.

Basic information

• Original name: Dynamika psychopatologie u prvních epizod schizofrenie
• Name in Czech: Dynamika psychopatologie u prvních epizod schizofrenie
• Name (in English): Psychopathology and treatment responsiveness of patients with first-episode schizophrenia
• Authors: ČEŠKOVÁ, Eva (203 Czech Republic, guarantor), Radovan PŘIKRYL (203 Czech Republic), Tomáš KAŠPÁREK (203 Czech Republic) and Hana KUČEROVÁ (203 Czech Republic).
• Edition: Bratislava, Psychiatria pre prax, p. 21 - 21, 1 pp. 2006.
• Publisher: Meduca, s. r. o.

Other information

• Original language: Czech
• Type of outcome: Proceedings paper
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/06:00016962
• Organization unit: Faculty of Medicine
• Keywords in English: first-episode schizophrenia; treatment response; psychopathology; remission
• Tags: first-episode schizophrenia, psychopathology, remission, treatment response

Abstract

U prvních episod schizofrenie došlo na konci akutní léčby k poklesu průměrné psychopatologie, po roce již k dalšímu poklesu nedošlo. U nonremitérů (n=23) bylo častější vysazení medikace a zhoršení pracovního statutu než u remitérů (n=73).Výsledek akutní léčby nemusí souviset s dalším vývojem onemocnění. Postupně se diferencují nemocní, u kterých je prognóza horší. Předmětem dalšího zkoumání je sledování biologických markerů, které by mohly odlišit tyto dvě skupiny již při iniciálním hodnocení.

Abstract (in English)

One hundred and four male patients hospitalized for the first time with the diagnosis of first-episode schizophrenia were comprehensively assessed on admission and discharge. Psychopathology, treatment response, and remission rater were evaluated. On admission, the most frequently observed symptoms were lack of judgment and insight, suspiciousness, conceptual disorganization, and active social avoidance. Except for negative symptoms, and comceptual disorganization correlated with the greatest number of discharge, the most frequent symptoms were again lack of judgment and insight,and for negative symptoms they were blunted affect, emotional withdrawal, and passive/apathetic social withdrawal. The positive symptoms of suspiciousness feelings of persecution and grandiosity persisted in of patients. On average, all symptoms were significantly reduced 44 days after admission. The negative symptoms improved less, compared with the positive ones. At discharge there was a high rate of responders: 73% and 74% of patients fulfilled the criteria for remission. On admission, the responders (n=76) had significantly higher scores of most symptoms, both positive and negative ones than nonresponders (N=28)

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.