VLKOVÁ, Marcela, Vojtěch THON, Mária ŠÁRFYOVÁ, Luděk BLÁHA, Adam SVOBODNÍK, Jindřich LOKAJ and Jiří LITZMAN. Age dependency and mutual relations in T- and B- lymphocyte abnormalities in CVID patients. Clin Exp Immunol. Blaskwell Synergy, vol. 143, No 2, p. 373-379. ISSN 0009-9104. 2006.
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Basic information
Original name Age dependency and mutual relations in T- and B- lymphocyte abnormalities in CVID patients
Name in Czech Vliv věku a vzájemné vztahy mezi abnormalitami T- a B- lymfocytů u běžného variabilního imunodeficitu
Authors VLKOVÁ, Marcela (203 Czech Republic), Vojtěch THON (203 Czech Republic), Mária ŠÁRFYOVÁ (703 Slovakia), Luděk BLÁHA (203 Czech Republic), Adam SVOBODNÍK (203 Czech Republic), Jindřich LOKAJ (203 Czech Republic) and Jiří LITZMAN (203 Czech Republic, guarantor).
Edition Clin Exp Immunol, Blaskwell Synergy, 2006, 0009-9104.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30102 Immunology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.747
RIV identification code RIV/00216224:14110/06:00018865
Organization unit Faculty of Medicine
UT WoS 000234647300023
Keywords (in Czech) běžná variabilní imunodeficience
Keywords in English Common variable immunodeficiency; T-lymphocyte subsets; B-lymphocyte subsets; differentiation antigens; age factor
Tags age factor, B-lymphocyte subsets, common variable immunodeficiency, differentiation antigens, T-lymphocyte subsets
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Jiří Litzman, CSc., učo 403. Changed: 2/4/2010 08:06.
Abstract
Common variable immunodeficiency (CVID) is primary hypogammaglobulinemia with unknown etiopathogenesis. Although various abnormalities of T- and B-cells were described, their pathogenetic roles are unclear. Markers associated with B-cell development were determined on B-lymphocytes (CD19+); T-lymphocyte development and activations markers were determined on CD4+ and CD8+ T-lymphocytes in 42 CVID patients and in 33 healthy controls. Abnormalities in CD4+ T-lymphocyte activation markers (increase in CD29, HLA-DR, CD45RO, decrease in CD27, CD62L, CD45RA) were particularly observed in patients with a decreased number of memory (CD27+) and mature (CD21+) B-cells (group Ia according to Freiburg classification), while abnormalities observed in CD8+ cells (increase in CD27 and CD28 and decrease in HLA-DR, CD57 and CD38) did not depend on grouping patients together according to B-lymphocyte developmental subpopulations. The expression of CD27 and CD45RA on CD4+ T-lymphocytes, such as the percentage of IgD+CD27- and IgD+CD27+ cells in B-lymphocytes, showed age dependency to be more significant than in the control group.
Abstract (in Czech)
Byly sledovány vztahy mezi abnormalitami počtů lymfocytárních subpopulací a expresí různých aktivačních a diferencičních znaků u pacientů s běžným variabilním imunodeficitem (CVID) a u kontrolních osob. Byl též prokáznán vliv věku pacientů na expresi antigenů CD45RA na CD4+ buněkách, stejně jako na některé B-lymfocytární subpopulace.
Links
NR7981, research and development projectName: Lymfocytární subpopulace u pacientů s humorálními imunodeficity
Investor: Ministry of Health of the CR
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