Detailed Information on Publication Record
2006
Age dependency and mutual relations in T- and B- lymphocyte abnormalities in CVID patients
VLKOVÁ, Marcela, Vojtěch THON, Mária ŠÁRFYOVÁ, Luděk BLÁHA, Adam SVOBODNÍK et. al.Basic information
Original name
Age dependency and mutual relations in T- and B- lymphocyte abnormalities in CVID patients
Name in Czech
Vliv věku a vzájemné vztahy mezi abnormalitami T- a B- lymfocytů u běžného variabilního imunodeficitu
Authors
VLKOVÁ, Marcela (203 Czech Republic), Vojtěch THON (203 Czech Republic), Mária ŠÁRFYOVÁ (703 Slovakia), Luděk BLÁHA (203 Czech Republic), Adam SVOBODNÍK (203 Czech Republic), Jindřich LOKAJ (203 Czech Republic) and Jiří LITZMAN (203 Czech Republic, guarantor)
Edition
Clin Exp Immunol, Blaskwell Synergy, 2006, 0009-9104
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30102 Immunology
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.747
RIV identification code
RIV/00216224:14110/06:00018865
Organization unit
Faculty of Medicine
UT WoS
000234647300023
Keywords (in Czech)
běžná variabilní imunodeficience
Keywords in English
Common variable immunodeficiency; T-lymphocyte subsets; B-lymphocyte subsets; differentiation antigens; age factor
Tags
Tags
International impact, Reviewed
Změněno: 2/4/2010 08:06, prof. MUDr. Jiří Litzman, CSc.
V originále
Common variable immunodeficiency (CVID) is primary hypogammaglobulinemia with unknown etiopathogenesis. Although various abnormalities of T- and B-cells were described, their pathogenetic roles are unclear. Markers associated with B-cell development were determined on B-lymphocytes (CD19+); T-lymphocyte development and activations markers were determined on CD4+ and CD8+ T-lymphocytes in 42 CVID patients and in 33 healthy controls. Abnormalities in CD4+ T-lymphocyte activation markers (increase in CD29, HLA-DR, CD45RO, decrease in CD27, CD62L, CD45RA) were particularly observed in patients with a decreased number of memory (CD27+) and mature (CD21+) B-cells (group Ia according to Freiburg classification), while abnormalities observed in CD8+ cells (increase in CD27 and CD28 and decrease in HLA-DR, CD57 and CD38) did not depend on grouping patients together according to B-lymphocyte developmental subpopulations. The expression of CD27 and CD45RA on CD4+ T-lymphocytes, such as the percentage of IgD+CD27- and IgD+CD27+ cells in B-lymphocytes, showed age dependency to be more significant than in the control group.
In Czech
Byly sledovány vztahy mezi abnormalitami počtů lymfocytárních subpopulací a expresí různých aktivačních a diferencičních znaků u pacientů s běžným variabilním imunodeficitem (CVID) a u kontrolních osob. Byl též prokáznán vliv věku pacientů na expresi antigenů CD45RA na CD4+ buněkách, stejně jako na některé B-lymfocytární subpopulace.
Links
| NR7981, research and development project |
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