BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, G. RAČKAUSKAS, Milena ŠIMURDOVÁ, Jiří ŠIMURDA a Marie NOVÁKOVÁ. The Effect Of Perphenazine On Transient Outward Potassium Current In Rat Ventricular Myocytes. In Analysis of Biomedical Signals and Images. 18. vyd. Brno: Vutium Press, Brno University of Technology, 2006, s. 364-366. ISBN 80-214-3152-0. |
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@inproceedings{693888, author = {Bébarová, Markéta and Matejovič, Peter and Pásek, Michal and Račkauskas, G. and Šimurdová, Milena and Šimurda, Jiří and Nováková, Marie}, address = {Brno}, booktitle = {Analysis of Biomedical Signals and Images}, edition = {18}, keywords = {rat ventricular myocyte; transient outward current; perphenazine}, language = {eng}, location = {Brno}, isbn = {80-214-3152-0}, pages = {364-366}, publisher = {Vutium Press, Brno University of Technology}, title = {The Effect Of Perphenazine On Transient Outward Potassium Current In Rat Ventricular Myocytes}, year = {2006} }
TY - JOUR ID - 693888 AU - Bébarová, Markéta - Matejovič, Peter - Pásek, Michal - Račkauskas, G. - Šimurdová, Milena - Šimurda, Jiří - Nováková, Marie PY - 2006 TI - The Effect Of Perphenazine On Transient Outward Potassium Current In Rat Ventricular Myocytes PB - Vutium Press, Brno University of Technology CY - Brno SN - 8021431520 KW - rat ventricular myocyte KW - transient outward current KW - perphenazine N2 - The aim of this study was to explore the effect of a phenothiazine neuroleptic drug perphenazine on transient outward potassium current Ito in rat ventricular myocytes. Perphenazine reversibly decreased the amplitude and accelerated the apparent inactivation of Ito in a concentration-dependent manner with EC50 = 26.4 +/- 3.5 umol/l and Hill coefficient n = 0.84 +/- 0.10 (evaluated from changes of time integral of Ito). Time course of Ito-inactivation was well fitted by a double exponential function; the fast time constant tf was significantly decreased under the effect of perphenazine and its concentration dependence was comparable with the concentration dependence of Ito-block represented by time integrals (EC50 = 26.8 +/- 8.2 umol/l, n = 0.88 +/- 0.28). It is suggested that perphenazine-induced block via open channel is very likely involved in the mechanism of drug-channel interaction. ER -
BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, G. RAČKAUSKAS, Milena ŠIMURDOVÁ, Jiří ŠIMURDA a Marie NOVÁKOVÁ. The Effect Of Perphenazine On Transient Outward Potassium Current In Rat Ventricular Myocytes. In \textit{Analysis of Biomedical Signals and Images}. 18. vyd. Brno: Vutium Press, Brno University of Technology, 2006, s.~364-366. ISBN~80-214-3152-0.
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