BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, G. RAČKAUSKAS, Milena ŠIMURDOVÁ, Jiří ŠIMURDA and Marie NOVÁKOVÁ. The Effect Of Perphenazine On Transient Outward Potassium Current In Rat Ventricular Myocytes. In Analysis of Biomedical Signals and Images. 18th ed. Brno: Vutium Press, Brno University of Technology, 2006, p. 364-366. ISBN 80-214-3152-0. |
Other formats:
BibTeX
LaTeX
RIS
@inproceedings{693888, author = {Bébarová, Markéta and Matejovič, Peter and Pásek, Michal and Račkauskas, G. and Šimurdová, Milena and Šimurda, Jiří and Nováková, Marie}, address = {Brno}, booktitle = {Analysis of Biomedical Signals and Images}, edition = {18}, keywords = {rat ventricular myocyte; transient outward current; perphenazine}, language = {eng}, location = {Brno}, isbn = {80-214-3152-0}, pages = {364-366}, publisher = {Vutium Press, Brno University of Technology}, title = {The Effect Of Perphenazine On Transient Outward Potassium Current In Rat Ventricular Myocytes}, year = {2006} }
TY - JOUR ID - 693888 AU - Bébarová, Markéta - Matejovič, Peter - Pásek, Michal - Račkauskas, G. - Šimurdová, Milena - Šimurda, Jiří - Nováková, Marie PY - 2006 TI - The Effect Of Perphenazine On Transient Outward Potassium Current In Rat Ventricular Myocytes PB - Vutium Press, Brno University of Technology CY - Brno SN - 8021431520 KW - rat ventricular myocyte KW - transient outward current KW - perphenazine N2 - The aim of this study was to explore the effect of a phenothiazine neuroleptic drug perphenazine on transient outward potassium current Ito in rat ventricular myocytes. Perphenazine reversibly decreased the amplitude and accelerated the apparent inactivation of Ito in a concentration-dependent manner with EC50 = 26.4 +/- 3.5 umol/l and Hill coefficient n = 0.84 +/- 0.10 (evaluated from changes of time integral of Ito). Time course of Ito-inactivation was well fitted by a double exponential function; the fast time constant tf was significantly decreased under the effect of perphenazine and its concentration dependence was comparable with the concentration dependence of Ito-block represented by time integrals (EC50 = 26.8 +/- 8.2 umol/l, n = 0.88 +/- 0.28). It is suggested that perphenazine-induced block via open channel is very likely involved in the mechanism of drug-channel interaction. ER -
BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, G. RAČKAUSKAS, Milena ŠIMURDOVÁ, Jiří ŠIMURDA and Marie NOVÁKOVÁ. The Effect Of Perphenazine On Transient Outward Potassium Current In Rat Ventricular Myocytes. In \textit{Analysis of Biomedical Signals and Images}. 18th ed. Brno: Vutium Press, Brno University of Technology, 2006, p.~364-366. ISBN~80-214-3152-0.
|