BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, G. RAČKAUSKAS, Milena ŠIMURDOVÁ, Jiří ŠIMURDA and Marie NOVÁKOVÁ. The Effect Of Perphenazine On Transient Outward Potassium Current In Rat Ventricular Myocytes. In Analysis of Biomedical Signals and Images. 18th ed. Brno: Vutium Press, Brno University of Technology, 2006, p. 364-366. ISBN 80-214-3152-0.
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Basic information
Original name The Effect Of Perphenazine On Transient Outward Potassium Current In Rat Ventricular Myocytes
Name in Czech Účinek perfenazinu na přechodný proud draslíku z buňky v komorových kardiomyocytech potkana
Authors BÉBAROVÁ, Markéta (203 Czech Republic), Peter MATEJOVIČ (703 Slovakia), Michal PÁSEK (203 Czech Republic), G. RAČKAUSKAS (233 Estonia), Milena ŠIMURDOVÁ (203 Czech Republic), Jiří ŠIMURDA (203 Czech Republic) and Marie NOVÁKOVÁ (203 Czech Republic, guarantor).
Edition 18. vyd. Brno, Analysis of Biomedical Signals and Images, p. 364-366, 3 pp. 2006.
Publisher Vutium Press, Brno University of Technology
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 30105 Physiology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/06:00015373
Organization unit Faculty of Medicine
ISBN 80-214-3152-0
Keywords in English rat ventricular myocyte; transient outward current; perphenazine
Tags Perphenazine, rat ventricular myocyte, transient outward current
Changed by Changed by: prof. MUDr. Marie Nováková, Ph.D., učo 1188. Changed: 29/8/2006 17:41.
Abstract
The aim of this study was to explore the effect of a phenothiazine neuroleptic drug perphenazine on transient outward potassium current Ito in rat ventricular myocytes. Perphenazine reversibly decreased the amplitude and accelerated the apparent inactivation of Ito in a concentration-dependent manner with EC50 = 26.4 +/- 3.5 umol/l and Hill coefficient n = 0.84 +/- 0.10 (evaluated from changes of time integral of Ito). Time course of Ito-inactivation was well fitted by a double exponential function; the fast time constant tf was significantly decreased under the effect of perphenazine and its concentration dependence was comparable with the concentration dependence of Ito-block represented by time integrals (EC50 = 26.8 +/- 8.2 umol/l, n = 0.88 +/- 0.28). It is suggested that perphenazine-induced block via open channel is very likely involved in the mechanism of drug-channel interaction.
Abstract (in Czech)
Cílem bylo studovat účinek perfenazinu, neuroleptika fenothiazinového typu, na přechodný proud draslíku z buňky Ito v buňce komorového myokardu potkana. Perfenazin reverzibilně snižoval amplitudu a koncentračně-závisle zrychloval zřejmou inaktivaci Ito s EC50 = 26.4 +/-3.5 umol/l a Hillovým koeficientem n = 0.84 +/- 0.10 (hodnoceno jako změny časového integrálu Ito). Časový průběh Ito-inaktivace je možné vyjádřit jako dvojitě exponenciální funkci; rychlá časová konstanta tf byla signifikantně snížena pod vlivem perfenazinu a její koncentrační závislost byla srovnatelná s koncentrační závislostí blokády Ito vyjádřené jako časové integrály (EC50 = 26.8 +/- 8.2 umol/l, n = 0.88 +/- 0.28). Předpokládáme, že látka pravděpodobně interaguje s kanálem v otevřeném stavu.
Links
AV0Z20760514, plan (intention)Name: Komplexní dynamické systémy v termodynamice, mechanice tekutin a těles
GA305/04/1385, research and development projectName: Modulační úloha sigma signalizace na elektromechanické vztahy izolovaného kardiomyocytu a srdce
Investor: Czech Science Foundation, Modulatory role of sigma signalling in electromechanical coupling of isolated cardiomyocyte and heart
MSM0021622402, plan (intention)Name: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases
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