| RHODES, Maria, Kamila REBLOVA, Walter NILS and Jiri SPONER. Trapped water molecules are essential to structural dynamics and function of a ribozyme. The Proceedings of the National Academy of Sciences. USA: National Academy of Sciences of the USA, 2006, vol. 103, No 36, p. 13380-13385. ISSN 1091-6490. |
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@article{693968,
author = {Rhodes, Maria and Reblova, Kamila and Nils, Walter and Sponer, Jiri},
article_location = {USA},
article_number = {36},
keywords = {coupled molecular motions; hairpin ribozyme; molecular dynamics; proton wire},
language = {eng},
issn = {1091-6490},
journal = {The Proceedings of the National Academy of Sciences},
title = {Trapped water molecules are essential to structural dynamics and function of a ribozyme},
volume = {103},
year = {2006}
}
TY - JOUR
ID - 693968
AU - Rhodes, Maria - Reblova, Kamila - Nils, Walter - Sponer, Jiri
PY - 2006
TI - Trapped water molecules are essential to structural dynamics and function of a ribozyme
JF - The Proceedings of the National Academy of Sciences
VL - 103
IS - 36
SP - 13380-13385
EP - 13380-13385
PB - National Academy of Sciences of the USA
SN - 10916490
KW - coupled molecular motions
KW - hairpin ribozyme
KW - molecular dynamics
KW - proton wire
N2 - Combining explicit-solvent molecular dynamics simulation and single molecule fluorescence spectroscopy approaches, we find that a ribozyme from a subviral plant pathogen exhibits a coupled hydrogen bonding network that communicates dynamic structural rearrangements throughout the catalytic core in response to site-specific chemical modification. Trapped long-residency water molecules are critical for this network.
ER -
RHODES, Maria, Kamila REBLOVA, Walter NILS and Jiri SPONER. Trapped water molecules are essential to structural dynamics and function of a ribozyme. \textit{The Proceedings of the National Academy of Sciences}. USA: National Academy of Sciences of the USA, 2006, vol.~103, No~36, p.~13380-13385. ISSN~1091-6490.
|
