RHODES, Maria, Kamila REBLOVA, Walter NILS and Jiri SPONER. Trapped water molecules are essential to structural dynamics and function of a ribozyme. The Proceedings of the National Academy of Sciences. USA: National Academy of Sciences of the USA, 2006, vol. 103, No 36, p. 13380-13385. ISSN 1091-6490. |
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@article{693968, author = {Rhodes, Maria and Reblova, Kamila and Nils, Walter and Sponer, Jiri}, article_location = {USA}, article_number = {36}, keywords = {coupled molecular motions; hairpin ribozyme; molecular dynamics; proton wire}, language = {eng}, issn = {1091-6490}, journal = {The Proceedings of the National Academy of Sciences}, title = {Trapped water molecules are essential to structural dynamics and function of a ribozyme}, volume = {103}, year = {2006} }
TY - JOUR ID - 693968 AU - Rhodes, Maria - Reblova, Kamila - Nils, Walter - Sponer, Jiri PY - 2006 TI - Trapped water molecules are essential to structural dynamics and function of a ribozyme JF - The Proceedings of the National Academy of Sciences VL - 103 IS - 36 SP - 13380-13385 EP - 13380-13385 PB - National Academy of Sciences of the USA SN - 10916490 KW - coupled molecular motions KW - hairpin ribozyme KW - molecular dynamics KW - proton wire N2 - Combining explicit-solvent molecular dynamics simulation and single molecule fluorescence spectroscopy approaches, we find that a ribozyme from a subviral plant pathogen exhibits a coupled hydrogen bonding network that communicates dynamic structural rearrangements throughout the catalytic core in response to site-specific chemical modification. Trapped long-residency water molecules are critical for this network. ER -
RHODES, Maria, Kamila REBLOVA, Walter NILS and Jiri SPONER. Trapped water molecules are essential to structural dynamics and function of a ribozyme. \textit{The Proceedings of the National Academy of Sciences}. USA: National Academy of Sciences of the USA, 2006, vol.~103, No~36, p.~13380-13385. ISSN~1091-6490.
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