PÁCAL, Lukáš, Kateřina KAŇKOVÁ and Andrea STEJSKALOVÁ. Role of genetic variability in antioxidant and DNA reparation enzymes in diabetic nephropathy. Diabetologia. Germany: Springer Verlag Berlin, 2006, vol. 49, Suppl. 1, p. 625-626. ISSN 0012-186X. |
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@article{695888, author = {Pácal, Lukáš and Kaňková, Kateřina and Stejskalová, Andrea}, article_location = {Germany}, article_number = {Suppl. 1}, keywords = {diabetes mellitus; nephropathy; oxidative stress}, language = {eng}, issn = {0012-186X}, journal = {Diabetologia}, title = {Role of genetic variability in antioxidant and DNA reparation enzymes in diabetic nephropathy}, volume = {49}, year = {2006} }
TY - JOUR ID - 695888 AU - Pácal, Lukáš - Kaňková, Kateřina - Stejskalová, Andrea PY - 2006 TI - Role of genetic variability in antioxidant and DNA reparation enzymes in diabetic nephropathy JF - Diabetologia VL - 49 IS - Suppl. 1 SP - 625-626 EP - 625-626 PB - Springer Verlag Berlin SN - 0012186X KW - diabetes mellitus KW - nephropathy KW - oxidative stress N2 - Diabetic nephropathy (DN) develops as a result of hemodynamic and metabolic changes accompanying diabetes. Hyperglycemia-induced overproduction of reactive oxygen species (ROS) is an important pathogenic determinant of DN. (In)efficient cellular protection by antioxidant enzymes is reflected in the overall extent of oxidative damage. Genetic variability in genes encoding antioxidant enzymes belong to functional candidates potentially modulating susceptibility to DN. Subsequently, oxidative DNA damage due to ROS overproduction activates DNA reparation. Unfortunately, this further aggravates cellular dysfunction/damage due to consumption of energy substrates and metabolic cofactors. The aim of the study was to investigate relationship between genetic variability in genes encoding poly-(ADP-ribose) polymerase (ADPRT), manganese superoxide dismutase (SOD2), catalase (CAT), glutathione S-transferases (GST) and susceptibility to DN. ER -
PÁCAL, Lukáš, Kateřina KAŇKOVÁ and Andrea STEJSKALOVÁ. Role of genetic variability in antioxidant and DNA reparation enzymes in diabetic nephropathy. \textit{Diabetologia}. Germany: Springer Verlag Berlin, 2006, vol.~49, Suppl. 1, p.~625-626. ISSN~0012-186X.
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