IZAKOVIČOVÁ HOLLÁ, Lydie, Andrea STEJSKALOVÁ, Vladimír ZNOJIL and Anna VAŠKŮ. Analysis of the inducible nitric oxide synthase gene polymorphisms in Czech patients with atopic diseases. Clin Exp Allergy. England: Blackwell Science, 2006, vol. 36, No 12, p. 1592-1601. ISSN 0954-7894.
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Basic information
Original name Analysis of the inducible nitric oxide synthase gene polymorphisms in Czech patients with atopic diseases
Name in Czech Analýza polymorfizmů v genu pro indukovatelnou formu syntetázy oxidu dusnatého u českých pacientů s atopickými chorobami
Authors IZAKOVIČOVÁ HOLLÁ, Lydie (203 Czech Republic, guarantor), Andrea STEJSKALOVÁ (203 Czech Republic), Vladimír ZNOJIL (203 Czech Republic) and Anna VAŠKŮ (203 Czech Republic).
Edition Clin Exp Allergy, England, Blackwell Science, 2006, 0954-7894.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30300 3.3 Health sciences
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.668
RIV identification code RIV/00216224:14330/06:00015859
Organization unit Faculty of Informatics
UT WoS 000243192800015
Keywords in English polymorphisms; asthma; atopic diseases; gene; iNOS
Tags asthma, atopic diseases, gene, iNOS, polymorphisms
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Lydie Izakovičová Hollá, Ph.D., učo 734. Changed: 17/6/2009 11:33.
Abstract
Nitric oxide (NO) is an important mediator of physiologic processes in the airways; it plays a significant role in the regulation of the Th1/Th2 balance and contributes to the development of atopic diseases. In this stude we analyzed several polymorphisms mainly in the promoter region of the inducible nitric oxide synthase (NOS2, iNOS) gene and investigated their associations with asthma and/or atopic phenotypes.
Abstract (in Czech)
Oxid dusnatý (NO) je důležitým mediátorem fyziologických procesů v dýchacích cestách; hraje význomnou úlohu v regulaci Th1/Th2 rovnováhy a podílí se na rozvoji atopických nemocí. V této práci jsme analyzovali několik polymorfizmů zejména v promotorové oblasti genu pro indukovatelnou formu syntetázy oxidu dusnatého (NOS2, iNOS) a zkoumali jejich vztah k astmatu a/nebo atopickým fenotypům.
Links
GA310/06/0827, research and development projectName: Genetické determinanty pro-/antioxidační rovnováhy v patogeneze respiračních nemocí
Investor: Czech Science Foundation
GP310/03/P045, research and development projectName: Analýza polymorfizmů v genech pro syntetázu oxidu dusnatého (NOS) u atopického astmatu a jiných alergií v české populaci
Investor: Czech Science Foundation
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