J 2006

Incidence of malignancy occurance in patients treated for infertility with assisted reproduction techniques

HUDEČEK, Robert, Pavel VENTRUBA, Constantinos TSOMPSOS, Eva RAČANSKÁ, Radka VAVRUŠOVÁ et. al.

Basic information

Original name

Incidence of malignancy occurance in patients treated for infertility with assisted reproduction techniques

Name in Czech

Incidence of malignancy occurance in patients treated for infertility with assisted reproduction techniques

Name (in English)

Incidence of malignancy occurance in patients treated for infertility with assisted reproduction techniques

Authors

HUDEČEK, Robert, Pavel VENTRUBA, Constantinos TSOMPSOS, Eva RAČANSKÁ, Radka VAVRUŠOVÁ and Karel NOVÁK

Edition

Helen. Jour. Obstet. Gynecol, Řecko, Helen. Jour. Obstet. Gynecol, 2006, 1109-4117

Other information

Language

řečtina stará

Type of outcome

Článek v odborném periodiku

Field of Study

30214 Obstetrics and gynaecology

Country of publisher

Greece

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Medicine

Keywords in English

Malignancy occurance; infertility; assisted reproduction techniques

Tags

International impact, Reviewed
Změněno: 10/1/2008 12:13, doc. MUDr. Robert Hudeček, Ph.D.

Abstract

V originále

The analysis of potential relation between assisted reproduction teqniques (ART) and enhanced risk of ovarian carcinoma (OC) was explored by data analysis of our University-based clinical register and National Oncology Register of Czech republic (NOR). Analyzed file includes data from 12.527 assisted reproduction treatment cycles performed at 4360 patients within years 1982-2004. After the reported malignancies number assessment from the observed group clinical database (ours and NOR) further processing, statistical analysis and results comparison was followed by the Institute of Health Information and Statistics of the Czech Republic. Statistical significance of malignancy occurance was evaluated using p-value<0.01. In the file of 4360 patients was reported 41 malignancies including 6 OC this is 3.454 times 95%CI[1.625 – 6.715] over the expected incidence to this diseased group of women. NOR offered the control diseased women group by the documented 4.236% rate among the total malignant women. It must be investigated by any reservedness whether the same risk of 3.454 developing OC exists at healthy general population women submitted to infertility treatment (p-value=0.004 Yates correction).

In Czech

The analysis of potential relation between assisted reproduction teqniques (ART) and enhanced risk of ovarian carcinoma (OC) was explored by data analysis of our University-based clinical register and National Oncology Register of Czech republic (NOR). Analyzed file includes data from 12.527 assisted reproduction treatment cycles performed at 4360 patients within years 1982-2004. After the reported malignancies number assessment from the observed group clinical database (ours and NOR) further processing, statistical analysis and results comparison was followed by the Institute of Health Information and Statistics of the Czech Republic. Statistical significance of malignancy occurance was evaluated using p-value<0.01. In the file of 4360 patients was reported 41 malignancies including 6 OC this is 3.454 times 95%CI[1.625 – 6.715] over the expected incidence to this diseased group of women. NOR offered the control diseased women group by the documented 4.236% rate among the total malignant women. It must be investigated by any reservedness whether the same risk of 3.454 developing OC exists at healthy general population women submitted to infertility treatment (p-value=0.004 Yates correction).

Links

NO7696, research and development project
Name: Ovariální karcinom a léčba neplodnosti metodami in vitro fertilizace - analýza rizikových faktorů pomocí systému pro dolování znalostí z databází SHLUK a umělé neuronové sítě NEUL 3