Endocannabinoid system activity and methamphetamine addiction

LANDA, Leoš, Karel ŠLAIS, Jana KUČEROVÁ and Alexandra ŠULCOVÁ. Endocannabinoid system activity and methamphetamine addiction. In Book of Abstracts. 2006.

Basic information

Original name

Endocannabinoid system activity and methamphetamine addiction

Name in Czech

Aktivita endokanabinoidního systému a metamfetaminová závislost

Authors

LANDA, Leoš (203 Czech Republic, guarantor), Karel ŠLAIS (203 Czech Republic), Jana KUČEROVÁ (203 Czech Republic) and Alexandra ŠULCOVÁ (203 Czech Republic)

Edition

Book of Abstracts, 2006

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Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Estonia

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/06:00017318

Organization unit

Faculty of Medicine

Keywords in English

behavioral sensitization; cannabinoids; methamphetamine; addiction

Tags

addiction, behavioral sensitization, cannabinoids, methamphetamine

Tags

International impact

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Abstract

V originále

Cannabinoid CB1 receptor stimulation by an agonist cross-sensitized to metamphetamine, while blocking of the CB1 receptor with an antagonist during the sensitizing phase with methamphetamine suppressed this phenomenon. The CB2 receptor agonist eliciting in our model of aggressivity behavioural effects did not cause cross-sensitization to methamphetamine.

In Czech

Stimulace kanabinoidního receptoru CB1 agonistou vyvolala zkříženou senzitizaci k účinkům metamfetaminu, zatímco zablokování CB1 receptoru antagonistou během senzitizační fáze metamfetaminem, tento fenomén potlačilo. Agonista CB2 receptorů vyvolávající v našem modelu agresivity behaviorální účinky zkříženou senzitizaci k metamfetaminu nezpůsobil.

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Links

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.