Different effects of MDMA or methamphetamine on aggressivity in mice repeatedly pretreated by MDMA

ŠLAIS, Karel, Leoš LANDA and Alexandra ŠULCOVÁ. Different effects of MDMA or methamphetamine on aggressivity in mice repeatedly pretreated by MDMA. In Books of Abstracts. 2006.

Basic information

• Original name: Different effects of MDMA or methamphetamine on aggressivity in mice repeatedly pretreated by MDMA
• Name in Czech: Různé účinky MDMA nebo metamfetaminu na agresivitu u myší po opakovaném podání MDMA
• Authors: ŠLAIS, Karel (203 Czech Republic, guarantor), Leoš LANDA (203 Czech Republic) and Alexandra ŠULCOVÁ (203 Czech Republic).
• Edition: Books of Abstracts, 2006.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Estonia
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/06:00017319
• Organization unit: Faculty of Medicine
• Keywords in English: methamphetamine; MDMA; agonistic behaviour; mice
• Tags: agonistic behaviour, MDMA, methamphetamine, mice
• Tags: International impact

Abstract

The challenge dose of MDMA inhibited all aggressive acts in isolates; the effects however were more pronounced in those repeatedly pre-treated with the vehicle. On the contrary, aggressivity increased after the “challenge“dose of vehicle in animals repeatedly administered MDMA. The challenge dose of methamphetamine also decreased all aggressive acts, in animals pretreated with MDMA more than after vehicle pretreatment.

Abstract (in Czech)

Provokující dávka MDMA inhibovala všechny agresivní prvky chování u myší chovaných izolovaně; tyto účinky však byly výraznější u těch jedinců, kteří byli opakovaně premedikováni vehikulem. Naopak, agresivita se zvýšila po provokující dávce vehikula u zvířat opakovaně premedikovaných MDMA. Provokující dávka metamfetaminu také snížila všechny agresivní prvky chování, u zvířat premedikovaných MDMA více než po premedikaci vehikulem.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.