Two candidate gene polymorphisms in ADHD children: a
case-control study of catechol-o-methyltransferase (COMT) and
monoamine oxidase B (MAOB) genes

J 2006

Two candidate gene polymorphisms in ADHD children: a case-control study of catechol-o-methyltransferase (COMT) and monoamine oxidase B (MAOB) genes

ŠTAIF, Radim, Ivana DRTÍLKOVÁ, Pavel THEINER, Renáta PITELOVÁ, Vladimír MIKEŠ et. al.

Basic information

Original name

Two candidate gene polymorphisms in ADHD children: a case-control study of catechol-o-methyltransferase (COMT) and monoamine oxidase B (MAOB) genes

Name in Czech

Dva kandidátní DNA polymorfizmy u dětí s ADHD: asociační studie genů pro COMT a MAOB

Authors

ŠTAIF, Radim (203 Czech Republic), Ivana DRTÍLKOVÁ (203 Czech Republic), Pavel THEINER (203 Czech Republic), Renáta PITELOVÁ (203 Czech Republic), Vladimír MIKEŠ (203 Czech Republic) and Omar ŠERÝ (203 Czech Republic, guarantor)

Edition

Archives of Medical Science, Poland, Termedia Publishing House, 2006, 1734-1922

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Poland

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/06:00018875

Organization unit

Faculty of Science

Keywords in English

ADHD; COMT; MAOB; polymorphism; gene

Abstract

ORIG CZ

V originále

Introduction: Attention deficit hyperactivity disorder (ADHD) is a common polygenic heritable disorder. We have investigated the relationship between ADHD and polymorphisms of catechol-O-methyltransferase (COMT) and monoaminooxidase B (MAOB) genes. It is well known that COMT and MAOB are metabolising enzymes that degrade biogenic amines and control the levels of these neurotransmitters in the central nervous system. An association has been previously observed between the Val158Met polymorphism of catechol-O-methyltransferase (COMT) gene and ADHD. The gene of monoamine oxidase B (MAOB) has been also suggested to play a role in psychiatric disorders and behavioral traits. Moreover, MAO inhibitors have been shown to be effective in the treatment of ADHD. Material and methods: 118 boys with ADHD and 153 controls aged from 7 to 13 years were included in this study. The PCR methods for the detection of the studied polymorphisms were used. Fisher-exact test was performed to assess the association between the studied groups. Results: There was no statistically significant difference in the genotype frequency of COMT (p=0.321) or MAOB (p=0.087) gene polymorphisms between the hyperactive group of boys and the control group of boys. Conclusion: Our study support the results of the previous studies: these two polymorphisms do not play the main role in the pathogenesis of ADHD.

In Czech

Na souboru 118 chlapců s ADHD a 153 chlapců z kontrolní skupiny jsme nenalezli vztah mezi ADHD a polymorfizmy genů pro COMT a MAOB.

Links

NF6520, research and development project

Name: Klinické a molekulárně-biologické koreláty hyperkinetické poruchy v dětském věku

Investor: Ministry of Health of the CR, Clinical and molecular-biological correlates of attention deficit hyperactivity disorder in children

Citovat

ŠTAIF, Radim, Ivana DRTÍLKOVÁ, Pavel THEINER, Renáta PITELOVÁ, Vladimír MIKEŠ and Omar ŠERÝ. Two candidate gene polymorphisms in ADHD children: a case-control study of catechol-o-methyltransferase (COMT) and monoamine oxidase B (MAOB) genes. Archives of Medical Science. Poland: Termedia Publishing House, 2006, vol. 2, No 4, p. 235-239. ISSN 1734-1922.

@article{698628,
   author = {Štaif, Radim and Drtílková, Ivana and Theiner, Pavel and Pitelová, Renáta and Mikeš, Vladimír and Šerý, Omar},
   article_location = {Poland},
   article_number = {4},
   keywords = {ADHD; COMT; MAOB; polymorphism; gene},
   language = {eng},
   issn = {1734-1922},
   journal = {Archives of Medical Science},
   title = {Two candidate gene polymorphisms in ADHD children: a case-control study of catechol-o-methyltransferase (COMT) and monoamine oxidase B (MAOB) genes},
   volume = {2},
   year = {2006}
}

TY  - JOUR
ID  - 698628
AU  - Štaif, Radim - Drtílková, Ivana - Theiner, Pavel - Pitelová, Renáta - Mikeš, Vladimír - Šerý, Omar
PY  - 2006
TI  - Two candidate gene polymorphisms in ADHD children: a case-control study of catechol-o-methyltransferase (COMT) and monoamine oxidase B (MAOB) genes
JF  - Archives of Medical Science
VL  - 2
IS  - 4
SP  - 235-239
EP  - 235-239
PB  - Termedia Publishing House
SN  - 17341922
KW  - ADHD
KW  - COMT
KW  - MAOB
KW  - polymorphism
KW  - gene
N2  - Introduction: Attention deficit hyperactivity disorder (ADHD) is a common polygenic heritable disorder. We have investigated the relationship between ADHD and polymorphisms of catechol-O-methyltransferase (COMT) and monoaminooxidase B (MAOB) genes. It is well known that COMT and MAOB are metabolising enzymes that degrade biogenic amines and control the levels of these neurotransmitters in the central nervous system. An association has been previously observed between the Val158Met polymorphism of catechol-O-methyltransferase (COMT) gene and ADHD. The gene of monoamine oxidase B (MAOB) has been also suggested to play a role in psychiatric disorders and behavioral traits. Moreover, MAO inhibitors have been shown to be effective in the treatment of ADHD. Material and methods: 118 boys with ADHD and 153 controls aged from 7 to 13 years were included in this study. The PCR methods for the detection of the studied polymorphisms were used. Fisher-exact test was performed to assess the association between the studied groups. Results: There was no statistically significant difference in the genotype frequency of COMT (p=0.321) or MAOB (p=0.087) gene polymorphisms between the hyperactive group of boys and the control group of boys. Conclusion: Our study support the results of the previous studies: these two polymorphisms do not play the main role in the pathogenesis of ADHD.
ER  -

ŠTAIF, Radim, Ivana DRTÍLKOVÁ, Pavel THEINER, Renáta PITELOVÁ, Vladimír MIKEŠ and Omar ŠERÝ. Two candidate gene polymorphisms in ADHD children: a case-control study of catechol-o-methyltransferase (COMT) and monoamine oxidase B (MAOB) genes. \textit{Archives of Medical Science}. Poland: Termedia Publishing House, 2006, vol.~2, No~4, p.~235-239. ISSN~1734-1922.

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