Detailed Information on Publication Record
2006
Srs2 protein and its multi-functional role in recombination/repair processes
KREJČÍ, LumírBasic information
Original name
Srs2 protein and its multi-functional role in recombination/repair processes
Name in Czech
Srs2 protein a jeho multi-funkční úlohy při rekombinaci a DNA opravě
Authors
Edition
Dubrovník, 2006
Publisher
HHMI
Other information
Language
English
Type of outcome
Audiovizuální tvorba
Field of Study
10600 1.6 Biological sciences
Country of publisher
Croatia
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Organization unit
Faculty of Science
Keywords in English
Srs2 protein; recombination; repair
Tags
Změněno: 31/3/2010 11:51, doc. Mgr. Lumír Krejčí, Ph.D.
V originále
Homologous recombination (HR) plays a key role in the elimination of cytotoxic and genotoxic lesions induced by ionizing radiation, carcinogenic chemicals, and chemotherapeutic compounds. Furthermore, cells have to rely on homologous recombination to rescue stalled replication forks and hence prevent fork demise. If not processed properly, DSBs can lead to chromosomal aberrations and rearrangements, which then give rise to strong mutator and cancer phenotypes. Genetic analyses in the yeast (Saccharomyces cerevisiae) have revealed a central role of the Srs2 helicase in preventing untimely HR events and the formation of potentially deleterious DNA structures upon DNA replication stress. In contrast, Srs2 function appears to be important also for proper repair of DNA double-strand breaks by HR. In this work, we aim to dissect the multi-functional role of Srs2 in HR and other cellular processes using combination of biochemical, genetic and structural approaches.
In Czech
Studium multi-funkční úlohy proteinu Srs2 při rekombinaci a DNA opravě.
Links
| LC06030, research and development project |
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| ME 888, research and development project |
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| MSM0021622413, plan (intention) |
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