ASSOCIATION OF LEPTIN GENETIC POLYMORPHISM -2548 G/A WITH GESTATIONAL DIABETES

BIENERTOVÁ VAŠKŮ, Julie, Anna VAŠKŮ, Zuzana DOSTÁLOVÁ and Petr BIENERT. ASSOCIATION OF LEPTIN GENETIC POLYMORPHISM -2548 G/A WITH GESTATIONAL DIABETES. Genes and Nutrition. New Century Health Publishers, 2006, 2/2006, No 2, p. 117-124, 5 pp. ISSN 1555-8932.

Basic information

• Original name: ASSOCIATION OF LEPTIN GENETIC POLYMORPHISM -2548 G/A WITH GESTATIONAL DIABETES
• Name in Czech: Asociace genetického polymorfismu -2548 G/A v genu pro leptin s gestačním diabetem
• Authors: BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, guarantor), Anna VAŠKŮ (203 Czech Republic), Zuzana DOSTÁLOVÁ (203 Czech Republic) and Petr BIENERT (203 Czech Republic).
• Edition: Genes and Nutrition, New Century Health Publishers, 2006, 1555-8932.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: Genetics and molecular biology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• RIV identification code: RIV/00216224:14110/06:00017421
• Organization unit: Faculty of Medicine
• UT WoS: 000258559500006
• Keywords in English: Gestational Diabetes Mellitus; Leptin; Polymorphism; Preeclampsia
• Tags: gestational diabetes mellitus, leptin, polymorphism, preeclampsia
• Tags: International impact, Reviewed

Abstract

The aim of this study was to investigate possible associations of -2548 G/A polymorphism in leptin gene promoter and pregnancy-associated diseases with abnormal fetal growth such as preeclampsia and gestational diabetes. The study was also focused on whether it is rather maternal or fetal variants that determines the pathological growth status. Peripheral or cord blood samples obtained from 49 preeclamptic women and their 39 newborns, 53 healthy controls and their 53 healthy newborns and 48 patients with gestational diabetes mellitus were evaluated for leptin gene (LEP) locus -2548 genotypes. The significantly higher risk for gestational diabetes mellitus was observed in the presence of an allele (AA and AG genotypes) against carriers of GG genotype (OR=2.84, 95%CI 1.14-7.07, p=0.02). There is a significant risk of diabetes mellitus associated to A allele (OR=1.79, 95%CI 1.02-3.14, p=0.03). Furthermore, evaluations of preeclamptic patients data revealed a significant association of genotype distribution and delivery and spontaneous abortion rate, where the GG carriers performed the highest pregnancy rate while the AG carriers performed the lowest spontaneous abortion rate. Our results support the hypothesis for -2548 G/A leptin gene polymorphism involvement in ethiopathogenesis of pregnancy-associated diseases with abnormal fetal growth, especially gestational diabetes mellitus.

Abstract (in Czech)

Získaná data naznačují, ze variabilita v genu pro leptin, konkrétně definovaný polymorfismus -2548 G/A se může uplatnit jako etiopatogenetický faktor při vzniku gestačního diabetu nebo obecně při poruchách fetálního růstu.

Links

• MSM 141100002, plan (intention): Name: Molekulární patofyziologie multigenních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases