KOURAFALOS, Vassilios N., Panagiotis MARAKOS, Emmanuel MIKROS, Nicole POULI, Jaromír MAREK and Radek MAREK. Synthesis and tautomerism study of 7-substituted pyrazolo[3,4-c]pyridines. Tetrahedron. Norwich: Elsevier Ltd., 2006, vol. 62, No 51, p. 11987-11993. ISSN 0040-4020.
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Basic information
Original name Synthesis and tautomerism study of 7-substituted pyrazolo[3,4-c]pyridines
Name in Czech Syntéza a tautomerní studie 7-substituovaných pyrazolo[3,4-c]pyridinů
Authors KOURAFALOS, Vassilios N. (300 Greece), Panagiotis MARAKOS (300 Greece), Emmanuel MIKROS (300 Greece), Nicole POULI (300 Greece), Jaromír MAREK (203 Czech Republic) and Radek MAREK (203 Czech Republic, guarantor).
Edition Tetrahedron, Norwich, Elsevier Ltd. 2006, 0040-4020.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10401 Organic chemistry
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.817
RIV identification code RIV/00216224:14310/06:00017425
Organization unit Faculty of Science
UT WoS 000242483100016
Keywords in English pyrazolo[3;4-c]pyridine; tautomerism; NMR spectroscopy; X-ray diffraction
Tags 4-c]pyridine, NMR Spectroscopy, pyrazolo[3, tautomerism, X-ray diffraction
Tags International impact, Reviewed
Changed by Changed by: prof. RNDr. Radek Marek, Ph.D., učo 381. Changed: 25/6/2009 12:06.
Abstract
A number of 7-substituted pyrazolo[3,4-c]pyridine derivatives have been synthesized in order to investigate the N1–N2 tautomerism within this class of biologically interesting compounds. Tautomeric equilibrium has been studied using NMR 13C, 15N chemical shifts and heteronuclear 1H–15N and 1H–13C spin–spin couplings, in conjunction with X-ray crystallography. The N1 tautomer predominates in DMF solution in all the compounds tested.
Abstract (in Czech)
A number of 7-substituted pyrazolo[3,4-c]pyridine derivatives have been synthesized in order to investigate the N1–N2 tautomerism within this class of biologically interesting compounds. Tautomeric equilibrium has been studied using NMR 13C, 15N chemical shifts and heteronuclear 1H–15N and 1H–13C spin–spin couplings, in conjunction with X-ray crystallography. The N1 tautomer predominates in DMF solution in all the compounds tested.
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LC06030, research and development projectName: Biomolekulární centrum
Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular centre
MSM0021622413, plan (intention)Name: Proteiny v metabolismu a při interakci organismů s prostředím
Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment
MSM0021622415, plan (intention)Name: Molekulární podstata buněčných a tkáňových regulací
Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations
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