A case-control study of the relationship between 13 candidate
genes and ADHD

J 2006

A case-control study of the relationship between 13 candidate genes and ADHD

ŠTAIF, Radim, Omar ŠERÝ, Renáta PITELOVÁ, Jan LOCHMAN, Vladimír MIKEŠ et. al.

Basic information

Original name

A case-control study of the relationship between 13 candidate genes and ADHD

Name in Czech

Asociační studie vztahu mezi 13 kandidátními geny a ADHD

Authors

ŠTAIF, Radim (203 Czech Republic), Omar ŠERÝ (203 Czech Republic, guarantor), Renáta PITELOVÁ (203 Czech Republic), Jan LOCHMAN (203 Czech Republic), Vladimír MIKEŠ (203 Czech Republic), Ivana DRTÍLKOVÁ (203 Czech Republic) and Pavel THEINER (203 Czech Republic)

Edition

American Journal of Medical Genetics, Hoboken, NJ, Wiley-Liss, Inc. 2006, 1552-4841

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 4.463

RIV identification code

RIV/00216224:14310/06:00017436

Organization unit

Faculty of Science

UT WoS

000240877700202

Keywords in English

ADHD; polymorphism; DAT1; DRD2; COMT; MAOB; ACE; ANG; CCR5; BDNF; MU; IL-2; IL-6; TNF; M235T

Abstract

ORIG CZ

V originále

Attention deficit hyperactivity disorder (ADHD) is a multifactorial disorder with significant genetic contribution. Dopamine genes have been the initial candidates based on the site of the action of the psychostimulant drugs. The other genes from neurotransmitter and immune system are in focus too. We have investigated whether there is an association between ADHD and polymorphisms of 13 candidate genes: DAT1, DRD2, COMT, MAOB, ACE, ANG, CCR5, BDNF, MU, IL-2, IL-6, TNF-alpha, and M235T. The aim of our case-control study was to determine whether the ADHD boys (118) have different genotype and alelic frequencies of examined polymorphisms of the above mentioned genes compared to controls (153). No significant differences were found between groups of boys in allelic and genotype frequencies of COMT, MAOB, ACE, ANG, CCR5, BDNF, MU, IL-2, IL-6, TNF-alpha and M235T genes (p < 0.05). For DAT1, the statistical analysis using Fisher exact test did not confirme the association of the previously possitive investigated 10-repeat allele or 10/10 genotype of DAT1 gene (p = 0.531). For DRD2, ADHD probands were more likely than controls to have the A1 allele and genotype A1A1 (p = 0.0013). Our results showed that ADHD in Czech children population is associated with TaqI A polymorphism of DRD2 gene. The presence of DRD2 A1 allele increases the risk of ADHD.

In Czech

Při zkoumání vztahu mezi ADHD a 13-ti polymorfizmy kandidátních genů jsme objevili vztah mezi genem pro DAT1, DRD2 a ADHD.

Links

MSM0021622413, plan (intention)

Name: Proteiny v metabolismu a při interakci organismů s prostředím

Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment

NR8137, research and development project

Name: Molekulární příčiny dispozic ke vzniku alkoholizmu.

Investor: Ministry of Health of the CR

Citovat

ŠTAIF, Radim, Omar ŠERÝ, Renáta PITELOVÁ, Jan LOCHMAN, Vladimír MIKEŠ, Ivana DRTÍLKOVÁ and Pavel THEINER. A case-control study of the relationship between 13 candidate genes and ADHD. American Journal of Medical Genetics. Hoboken, NJ: Wiley-Liss, Inc., 2006, 141B, No 7, p. 729-730. ISSN 1552-4841.

@article{699930,
   author = {Štaif, Radim and Šerý, Omar and Pitelová, Renáta and Lochman, Jan and Mikeš, Vladimír and Drtílková, Ivana and Theiner, Pavel},
   article_location = {Hoboken, NJ},
   article_number = {7},
   keywords = {ADHD; polymorphism; DAT1; DRD2; COMT; MAOB; ACE; ANG; CCR5; BDNF; MU; IL-2; IL-6; TNF; M235T},
   language = {eng},
   issn = {1552-4841},
   journal = {American Journal of Medical Genetics},
   title = {A case-control study of the relationship between 13 candidate genes and ADHD},
   volume = {141B},
   year = {2006}
}

TY  - JOUR
ID  - 699930
AU  - Štaif, Radim - Šerý, Omar - Pitelová, Renáta - Lochman, Jan - Mikeš, Vladimír - Drtílková, Ivana - Theiner, Pavel
PY  - 2006
TI  - A case-control study of the relationship between 13 candidate genes and ADHD
JF  - American Journal of Medical Genetics
VL  - 141B
IS  - 7
SP  - 729-730
EP  - 729-730
PB  - Wiley-Liss, Inc.
SN  - 15524841
KW  - ADHD
KW  - polymorphism
KW  - DAT1
KW  - DRD2
KW  - COMT
KW  - MAOB
KW  - ACE
KW  - ANG
KW  - CCR5
KW  - BDNF
KW  - MU
KW  - IL-2
KW  - IL-6
KW  - TNF
KW  - M235T
N2  - Attention deficit hyperactivity disorder (ADHD) is a multifactorial disorder with significant genetic contribution. Dopamine genes have been the initial candidates based on the site of the action of the psychostimulant drugs. The other genes from neurotransmitter and immune system are in focus too. We have investigated whether there is an association between ADHD and polymorphisms of 13 candidate genes: DAT1, DRD2, COMT, MAOB, ACE, ANG, CCR5, BDNF, MU, IL-2, IL-6, TNF-alpha, and M235T. The aim of our case-control study was to determine whether the ADHD boys (118) have different genotype and alelic frequencies of examined polymorphisms of the above mentioned genes compared to controls (153). No significant differences were found between groups of boys in allelic and genotype frequencies of COMT, MAOB, ACE, ANG, CCR5, BDNF, MU, IL-2, IL-6, TNF-alpha and M235T genes (p < 0.05). For DAT1, the statistical analysis using Fisher exact test did not confirme the association of the previously possitive investigated 10-repeat allele or 10/10 genotype of DAT1 gene (p = 0.531). For DRD2, ADHD probands were more likely than controls to have the A1 allele and genotype A1A1 (p = 0.0013). Our results showed that ADHD in Czech children population is associated with TaqI A polymorphism of DRD2 gene. The presence of DRD2 A1 allele increases the risk of ADHD.
ER  -

ŠTAIF, Radim, Omar ŠERÝ, Renáta PITELOVÁ, Jan LOCHMAN, Vladimír MIKEŠ, Ivana DRTÍLKOVÁ and Pavel THEINER. A case-control study of the relationship between 13 candidate genes and ADHD. \textit{American Journal of Medical Genetics}. Hoboken, NJ: Wiley-Liss, Inc., 2006, 141B, No~7, p.~729-730. ISSN~1552-4841.

Detailed Information on Publication Record