New Frequent polymorphism 1765C/T in the Gene Encoding For Transcriptional Represson Oncoprotein Gfi-1 in Cutaneous T-cell Lymphomas (CTCL)

BIENERTOVÁ VAŠKŮ, Julie, Vladimír VAŠKŮ, Lydie IZAKOVIČOVÁ HOLLÁ and Anna VAŠKŮ. New Frequent polymorphism 1765C/T in the Gene Encoding For Transcriptional Represson Oncoprotein Gfi-1 in Cutaneous T-cell Lymphomas (CTCL). In The Journal of Investigative Dermatology. London: European Society for Dermatological Research, 2004, p. 56-56.

Basic information

Original name

New Frequent polymorphism 1765C/T in the Gene Encoding For Transcriptional Represson Oncoprotein Gfi-1 in Cutaneous T-cell Lymphomas (CTCL)

Name in Czech

Nový častý polymorfismus 1765 C/T v nekódující oblasti genu pro transkripční represorový onkoprotein Gfi-1 u pacientů s kožními T-lymfomy

Authors

BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, guarantor), Vladimír VAŠKŮ (203 Czech Republic), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic) and Anna VAŠKŮ (203 Czech Republic)

Edition

London, The Journal of Investigative Dermatology, p. 56-56, 1 pp. 2004

Publisher

European Society for Dermatological Research

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Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

Genetics and molecular biology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/04:00021722

Organization unit

Faculty of Medicine

UT WoS

000222483400362

Keywords in English

Gfi-1; gene; polymorphism; cutaneous T-cell lymphoma

Tags

cutaneous T-cell lymphoma, gene, Gfi-1, polymorphism

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Abstract

V originále

The allelic variant T of 1765 C/T polymorphism is characterized by extinction of the binding site for AP-1 protein in 3-region of Gfi-1 gene. The homozygote genotype TT seems to be associated with lower OR for CTCL. Therefore, the TT genotype of 1765 C/T polymorphism of Gfi-1 gene may have potentially protective effect against CTCL

In Czech

The allelic variant T of 1765 C/T polymorphism is characterized by extinction of the binding site for AP-1 protein in 3-region of Gfi-1 gene. The homozygote genotype TT seems to be associated with lower OR for CTCL. Therefore, the TT genotype of 1765 C/T polymorphism of Gfi-1 gene may have potentially protective effect against CTCL

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Links

MSM 141100002, plan (intention)

Name: Molekulární patofyziologie multigenních chorob Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases