BIENERTOVÁ VAŠKŮ, Julie, Vladimír VAŠKŮ, Lydie IZAKOVIČOVÁ HOLLÁ and Anna VAŠKŮ. New Frequent polymorphism 1765C/T in the Gene Encoding For Transcriptional Represson Oncoprotein Gfi-1 in Cutaneous T-cell Lymphomas (CTCL). In The Journal of Investigative Dermatology. London: European Society for Dermatological Research. p. 56-56. 2004.
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Basic information
Original name New Frequent polymorphism 1765C/T in the Gene Encoding For Transcriptional Represson Oncoprotein Gfi-1 in Cutaneous T-cell Lymphomas (CTCL)
Name in Czech Nový častý polymorfismus 1765 C/T v nekódující oblasti genu pro transkripční represorový onkoprotein Gfi-1 u pacientů s kožními T-lymfomy
Authors BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, guarantor), Vladimír VAŠKŮ (203 Czech Republic), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic) and Anna VAŠKŮ (203 Czech Republic).
Edition London, The Journal of Investigative Dermatology, p. 56-56, 1 pp. 2004.
Publisher European Society for Dermatological Research
Other information
Original language English
Type of outcome Proceedings paper
Field of Study Genetics and molecular biology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/04:00021722
Organization unit Faculty of Medicine
UT WoS 000222483400362
Keywords in English Gfi-1; gene; polymorphism; cutaneous T-cell lymphoma
Tags cutaneous T-cell lymphoma, gene, Gfi-1, polymorphism
Changed by Changed by: prof. MUDr. Lydie Izakovičová Hollá, Ph.D., učo 734. Changed: 17/6/2009 11:50.
Abstract
The allelic variant T of 1765 C/T polymorphism is characterized by extinction of the binding site for AP-1 protein in 3-region of Gfi-1 gene. The homozygote genotype TT seems to be associated with lower OR for CTCL. Therefore, the TT genotype of 1765 C/T polymorphism of Gfi-1 gene may have potentially protective effect against CTCL
Abstract (in Czech)
The allelic variant T of 1765 C/T polymorphism is characterized by extinction of the binding site for AP-1 protein in 3-region of Gfi-1 gene. The homozygote genotype TT seems to be associated with lower OR for CTCL. Therefore, the TT genotype of 1765 C/T polymorphism of Gfi-1 gene may have potentially protective effect against CTCL
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MSM 141100002, plan (intention)Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases
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