Detailed Information on Publication Record
2006
Inzerčně deleční polymorfimus v genu pro angiotensin konvertující enzym ID ACE u těhotných žen s gestačním diabetem
DOSTÁLOVÁ, Zuzana, Julie BIENERTOVÁ VAŠKŮ, Anna VAŠKŮ, Romana GERYCHOVÁ, Vít UNZEITIG et. al.Basic information
Original name
Inzerčně deleční polymorfimus v genu pro angiotensin konvertující enzym ID ACE u těhotných žen s gestačním diabetem
Name in Czech
Inzerčně deleční polymorfimus v genu pro angiotensin konvertující enzym ID ACE u těhotných žen s gestačním diabetem
Name (in English)
Insertion deletion polymorphism in the gene for angiotensin converning enzyme (ID ACE) in pregnant women with gestational diabetes
Authors
DOSTÁLOVÁ, Zuzana (203 Czech Republic), Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, guarantor), Anna VAŠKŮ (203 Czech Republic), Romana GERYCHOVÁ (203 Czech Republic) and Vít UNZEITIG (203 Czech Republic)
Edition
Česká Gynekologie, Praha, Česká gynekologická společnost, 2006, 1210-7832
Other information
Language
Czech
Type of outcome
Článek v odborném periodiku
Field of Study
Genetics and molecular biology
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14110/06:00017446
Organization unit
Faculty of Medicine
Keywords in English
Angiotensin-converting enzyme; gene polymorphism; gestational diabetes mellitus; pregnancy; renin-angiotensin system
Tags
Změněno: 3/11/2006 12:42, prof. MUDr. Julie Dobrovolná, Ph.D.
V originále
Na základě našich výsledků se polymorfismus ID v genu pro ACE nejeví jako významný genetický marker rizika pro gestační diabetes.
In English
Aim of the study: The aim of the study was to investigate possible associations of the Angiotensin - converting enzyme insertion/deletion (I/D ACE) polymorphism with gestational diabetes mellitus occurrence. Methods: Number of 53 healthy pregnant women (controls) and 48 women with gestational diabetes mellitus were included in the study. The woman patients were hospitalised in the Clinic of Obstetrics and Gynaecology, Masaryk University Affiliated hospital Brno during the period 10/2004 - 10/2005. In all cases there was the spontaneous one baby pregnancy. The procedure was obtaining the peripheral blood samples from women of those two groups and isolation of their DNA using standard technique with the use of proteinase K. I/D ACE genotype of each person was determined using allele specific primers. Results: We did not prove significant association neither of the genotype distribution (Pg) Pg = 0.115 nor allele frequency (Pa) Pa = 0.873 between controls and women with gestational diabetes mellitus. The significant differences of genotype distributions (Pg=0.03) were observed in women with two and more labours in anamnesis. Borderline significant differences of genotype distributions (Pg=0.08) were found in women with one and more abortions in anamnesis. Conclusions: According to our results the variability in ACE gene can be taken as factor contributing to manifestation of gestational diabetes mellitus. According to results of our study I/D ACE polymorphism can't be taken as genetic marker of gestational diabetes mellitus.
Links
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