Quantitative Structure-Activity Relationships for Toxicity and Genotoxicity of Halogenated Aliphatic Compounds: Wing Spot Test of Drosophila melanogaster.

CHROUST, Karel, Martina PAVLOVÁ, Zbyněk PROKOP, Jan MENDEL, Kateřina BOŽKOVÁ, Zdeněk KUBÁT, Věra ZAJÍČKOVÁ and Jiří DAMBORSKÝ. Quantitative Structure-Activity Relationships for Toxicity and Genotoxicity of Halogenated Aliphatic Compounds: Wing Spot Test of Drosophila melanogaster. CHEMOSPHERE. 2007, vol. 67, No 1, p. 152-159. ISSN 0045-6535.

Basic information

• Original name: Quantitative Structure-Activity Relationships for Toxicity and Genotoxicity of Halogenated Aliphatic Compounds: Wing Spot Test of Drosophila melanogaster.
• Name in Czech: QSAR pro toxicitu a genotoxicitu halogenovaných alifatických sloučenin:"Wing Spot Test" na Drosophila melanogaster.
• Authors: CHROUST, Karel (203 Czech Republic), Martina PAVLOVÁ (203 Czech Republic), Zbyněk PROKOP (203 Czech Republic), Jan MENDEL (203 Czech Republic), Kateřina BOŽKOVÁ (203 Czech Republic), Zdeněk KUBÁT (203 Czech Republic), Věra ZAJÍČKOVÁ (203 Czech Republic) and Jiří DAMBORSKÝ (203 Czech Republic, guarantor).
• Edition: CHEMOSPHERE, 2007, 0045-6535.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10600 1.6 Biological sciences
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 2.739
• RIV identification code: RIV/00216224:14310/07:00021727
• Organization unit: Faculty of Science
• UT WoS: 000244636100017
• Keywords in English: Halogenated aliphatic compounds; toxic; genotoxic effects; Drosophila melanogaster
• Tags: Drosophila melanogaster, genotoxic effects, Halogenated aliphatic compounds, toxic
• Tags: Reviewed

Abstract

Halogenated aliphatic compounds were evaluated for toxic and genotoxic effects in the somatic mutation and recombination test employing Drosophila melanogaster. The tested chemicals included chlorinated, brominated and iodinated; mono-, di- and tri-substituted; saturated and unsaturated alkanes: 1,2-dibromoethane, 1-bromo-2-chloroethane, 1-iodopropane, 2,3-dichloropropene, 3-bromo-1-propene, epibromohydrin, 2-iodobutane, 3-chloro-2-methylpropene, 1,2,3-trichloropropane, 1,2-dichloroethane, 1,2-dichlorobutane, 1-chloro-2-methylpropane, 1,3-dichloropropane, 1,2-dichloropropane, 2-chloroethymethylether, 1-bromo-2-methylpropane and 1-chloropentane. N-methyl-N-nitrosourea served as the positive and distilled water as the negative control. The set of chemicals for the toxicological testing was selected by the use of statistical experiment design. Group of unsaturated aliphatic hydrocarbons were generally more toxic than saturated analogues. The genotoxic effect was observed with 14 compounds in the wing spot test, while 3 substances did not show any genotoxicity by using wing spot test at 50% lethal concentration. The highest number of wing spots was observed in genotoxicity assay with 1-bromo-2-chloroethane, 1,2-dichloroethane, 1,2-dibromoethane and 1-iodopropane. Nucleophilic superdelocalizability calculated by quantum mechanics appears to be a good parameter for prediction of both toxicity and genotoxicity effects of halogenated aliphatic compounds.

Abstract (in Czech)

U halogenovaných alifatických sloučenin byly hodnoceny toxické a genotoxické efekty na somatické mutace a rekombinace u Drosophil melanogaster. Test chemikálií zahrnoval chlorované, bromované a iodované, mono-, di- a tri- substituenty.

Links

• MSM0021622412, plan (intention): Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL)

Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)