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@article{700042, author = {Chroust, Karel and Pavlová, Martina and Prokop, Zbyněk and Mendel, Jan and Božková, Kateřina and Kubát, Zdeněk and Zajíčková, Věra and Damborský, Jiří}, article_number = {1}, keywords = {Halogenated aliphatic compounds; toxic; genotoxic effects; Drosophila melanogaster}, language = {eng}, issn = {0045-6535}, journal = {CHEMOSPHERE}, title = {Quantitative Structure-Activity Relationships for Toxicity and Genotoxicity of Halogenated Aliphatic Compounds: Wing Spot Test of Drosophila melanogaster.}, url = {http://loschmidt.chemi.muni.cz/peg/abstracts/chemosph06.html}, volume = {67}, year = {2007} }
TY - JOUR ID - 700042 AU - Chroust, Karel - Pavlová, Martina - Prokop, Zbyněk - Mendel, Jan - Božková, Kateřina - Kubát, Zdeněk - Zajíčková, Věra - Damborský, Jiří PY - 2007 TI - Quantitative Structure-Activity Relationships for Toxicity and Genotoxicity of Halogenated Aliphatic Compounds: Wing Spot Test of Drosophila melanogaster. JF - CHEMOSPHERE VL - 67 IS - 1 SP - 152-159 EP - 152-159 SN - 00456535 KW - Halogenated aliphatic compounds KW - toxic KW - genotoxic effects KW - Drosophila melanogaster UR - http://loschmidt.chemi.muni.cz/peg/abstracts/chemosph06.html N2 - Halogenated aliphatic compounds were evaluated for toxic and genotoxic effects in the somatic mutation and recombination test employing Drosophila melanogaster. The tested chemicals included chlorinated, brominated and iodinated; mono-, di- and tri-substituted; saturated and unsaturated alkanes: 1,2-dibromoethane, 1-bromo-2-chloroethane, 1-iodopropane, 2,3-dichloropropene, 3-bromo-1-propene, epibromohydrin, 2-iodobutane, 3-chloro-2-methylpropene, 1,2,3-trichloropropane, 1,2-dichloroethane, 1,2-dichlorobutane, 1-chloro-2-methylpropane, 1,3-dichloropropane, 1,2-dichloropropane, 2-chloroethymethylether, 1-bromo-2-methylpropane and 1-chloropentane. N-methyl-N-nitrosourea served as the positive and distilled water as the negative control. The set of chemicals for the toxicological testing was selected by the use of statistical experiment design. Group of unsaturated aliphatic hydrocarbons were generally more toxic than saturated analogues. The genotoxic effect was observed with 14 compounds in the wing spot test, while 3 substances did not show any genotoxicity by using wing spot test at 50% lethal concentration. The highest number of wing spots was observed in genotoxicity assay with 1-bromo-2-chloroethane, 1,2-dichloroethane, 1,2-dibromoethane and 1-iodopropane. Nucleophilic superdelocalizability calculated by quantum mechanics appears to be a good parameter for prediction of both toxicity and genotoxicity effects of halogenated aliphatic compounds. ER -
CHROUST, Karel, Martina PAVLOVÁ, Zbyněk PROKOP, Jan MENDEL, Kateřina BOŽKOVÁ, Zdeněk KUBÁT, Věra ZAJÍČKOVÁ and Jiří DAMBORSKÝ. Quantitative Structure-Activity Relationships for Toxicity and Genotoxicity of Halogenated Aliphatic Compounds: Wing Spot Test of Drosophila melanogaster. \textit{CHEMOSPHERE}. 2007, vol.~67, No~1, p.~152-159. ISSN~0045-6535.
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