Quantitative Structure-Activity Relationships for Toxicity and
Genotoxicity of Halogenated Aliphatic Compounds: Wing Spot Test
of Drosophila melanogaster.

J 2007

Quantitative Structure-Activity Relationships for Toxicity and Genotoxicity of Halogenated Aliphatic Compounds: Wing Spot Test of Drosophila melanogaster.

CHROUST, Karel, Martina PAVLOVÁ, Zbyněk PROKOP, Jan MENDEL, Kateřina BOŽKOVÁ et. al.

Basic information

Original name

Quantitative Structure-Activity Relationships for Toxicity and Genotoxicity of Halogenated Aliphatic Compounds: Wing Spot Test of Drosophila melanogaster.

Name in Czech

QSAR pro toxicitu a genotoxicitu halogenovaných alifatických sloučenin:"Wing Spot Test" na Drosophila melanogaster.

Authors

CHROUST, Karel (203 Czech Republic), Martina PAVLOVÁ (203 Czech Republic), Zbyněk PROKOP (203 Czech Republic), Jan MENDEL (203 Czech Republic), Kateřina BOŽKOVÁ (203 Czech Republic), Zdeněk KUBÁT (203 Czech Republic), Věra ZAJÍČKOVÁ (203 Czech Republic) and Jiří DAMBORSKÝ (203 Czech Republic, guarantor)

Edition

CHEMOSPHERE, 2007, 0045-6535

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.739

RIV identification code

RIV/00216224:14310/07:00021727

Organization unit

Faculty of Science

UT WoS

000244636100017

Keywords in English

Halogenated aliphatic compounds; toxic; genotoxic effects; Drosophila melanogaster

Abstract

ORIG CZ

V originále

Halogenated aliphatic compounds were evaluated for toxic and genotoxic effects in the somatic mutation and recombination test employing Drosophila melanogaster. The tested chemicals included chlorinated, brominated and iodinated; mono-, di- and tri-substituted; saturated and unsaturated alkanes: 1,2-dibromoethane, 1-bromo-2-chloroethane, 1-iodopropane, 2,3-dichloropropene, 3-bromo-1-propene, epibromohydrin, 2-iodobutane, 3-chloro-2-methylpropene, 1,2,3-trichloropropane, 1,2-dichloroethane, 1,2-dichlorobutane, 1-chloro-2-methylpropane, 1,3-dichloropropane, 1,2-dichloropropane, 2-chloroethymethylether, 1-bromo-2-methylpropane and 1-chloropentane. N-methyl-N-nitrosourea served as the positive and distilled water as the negative control. The set of chemicals for the toxicological testing was selected by the use of statistical experiment design. Group of unsaturated aliphatic hydrocarbons were generally more toxic than saturated analogues. The genotoxic effect was observed with 14 compounds in the wing spot test, while 3 substances did not show any genotoxicity by using wing spot test at 50% lethal concentration. The highest number of wing spots was observed in genotoxicity assay with 1-bromo-2-chloroethane, 1,2-dichloroethane, 1,2-dibromoethane and 1-iodopropane. Nucleophilic superdelocalizability calculated by quantum mechanics appears to be a good parameter for prediction of both toxicity and genotoxicity effects of halogenated aliphatic compounds.

In Czech

U halogenovaných alifatických sloučenin byly hodnoceny toxické a genotoxické efekty na somatické mutace a rekombinace u Drosophil melanogaster. Test chemikálií zahrnoval chlorované, bromované a iodované, mono-, di- a tri- substituenty.

Links

MSM0021622412, plan (intention)

Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL)

Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)

Citovat

CHROUST, Karel, Martina PAVLOVÁ, Zbyněk PROKOP, Jan MENDEL, Kateřina BOŽKOVÁ, Zdeněk KUBÁT, Věra ZAJÍČKOVÁ and Jiří DAMBORSKÝ. Quantitative Structure-Activity Relationships for Toxicity and Genotoxicity of Halogenated Aliphatic Compounds: Wing Spot Test of Drosophila melanogaster. CHEMOSPHERE. 2007, vol. 67, No 1, p. 152-159. ISSN 0045-6535.

@article{700042,
   author = {Chroust, Karel and Pavlová, Martina and Prokop, Zbyněk and Mendel, Jan and Božková, Kateřina and Kubát, Zdeněk and Zajíčková, Věra and Damborský, Jiří},
   article_number = {1},
   keywords = {Halogenated aliphatic compounds; toxic; genotoxic effects; Drosophila melanogaster},
   language = {eng},
   issn = {0045-6535},
   journal = {CHEMOSPHERE},
   title = {Quantitative Structure-Activity Relationships for Toxicity and Genotoxicity of Halogenated Aliphatic Compounds: Wing Spot Test of Drosophila melanogaster.},
   url = {http://loschmidt.chemi.muni.cz/peg/abstracts/chemosph06.html},
   volume = {67},
   year = {2007}
}

TY  - JOUR
ID  - 700042
AU  - Chroust, Karel - Pavlová, Martina - Prokop, Zbyněk - Mendel, Jan - Božková, Kateřina - Kubát, Zdeněk - Zajíčková, Věra - Damborský, Jiří
PY  - 2007
TI  - Quantitative Structure-Activity Relationships for Toxicity and Genotoxicity of Halogenated Aliphatic Compounds: Wing Spot Test of Drosophila melanogaster.
JF  - CHEMOSPHERE
VL  - 67
IS  - 1
SP  - 152-159
EP  - 152-159
SN  - 00456535
KW  - Halogenated aliphatic compounds
KW  - toxic
KW  - genotoxic effects
KW  - Drosophila melanogaster
UR  - http://loschmidt.chemi.muni.cz/peg/abstracts/chemosph06.html
N2  - Halogenated aliphatic compounds were evaluated for toxic and genotoxic effects in the somatic mutation and recombination test employing Drosophila melanogaster. The tested chemicals included chlorinated, brominated and iodinated; mono-, di- and tri-substituted; saturated and unsaturated alkanes: 1,2-dibromoethane, 1-bromo-2-chloroethane, 1-iodopropane, 2,3-dichloropropene, 3-bromo-1-propene, epibromohydrin, 2-iodobutane, 3-chloro-2-methylpropene, 1,2,3-trichloropropane, 1,2-dichloroethane, 1,2-dichlorobutane, 1-chloro-2-methylpropane, 1,3-dichloropropane, 1,2-dichloropropane, 2-chloroethymethylether, 1-bromo-2-methylpropane and 1-chloropentane. N-methyl-N-nitrosourea served as the positive and distilled water as the negative control. The set of chemicals for the toxicological testing was selected by the use of statistical experiment design. Group of unsaturated aliphatic hydrocarbons were generally more toxic than saturated analogues. The genotoxic effect was observed with 14 compounds in the wing spot test, while 3 substances did not show any genotoxicity by using wing spot test at 50% lethal concentration. The highest number of wing spots was observed in genotoxicity assay with 1-bromo-2-chloroethane, 1,2-dichloroethane, 1,2-dibromoethane and 1-iodopropane. Nucleophilic superdelocalizability calculated by quantum mechanics appears to be a good parameter for prediction of both toxicity and genotoxicity effects of halogenated aliphatic compounds.
ER  -

CHROUST, Karel, Martina PAVLOVÁ, Zbyněk PROKOP, Jan MENDEL, Kateřina BOŽKOVÁ, Zdeněk KUBÁT, Věra ZAJÍČKOVÁ and Jiří DAMBORSKÝ. Quantitative Structure-Activity Relationships for Toxicity and Genotoxicity of Halogenated Aliphatic Compounds: Wing Spot Test of Drosophila melanogaster. \textit{CHEMOSPHERE}. 2007, vol.~67, No~1, p.~152-159. ISSN~0045-6535.

Detailed Information on Publication Record