J 2006

Influencing negative symptoms of schizophrenia with repetitive transcranial magnetic stimulation: a pilot study

PŘIKRYL, Radovan, Libor USTOHAL, Tomáš KAŠPÁREK, Hana KUČEROVÁ, Eva ČEŠKOVÁ et. al.

Basic information

Original name

Influencing negative symptoms of schizophrenia with repetitive transcranial magnetic stimulation: a pilot study

Name in Czech

Ovlivnění negativních příznaků schizofrenie pomocí rTMS: pilotní studie

Name (in English)

Influencing negative symptoms of schizophrenia with repetitive transcranial magnetic stimulation: a pilot study

Authors

PŘIKRYL, Radovan (203 Czech Republic, guarantor), Libor USTOHAL (203 Czech Republic), Tomáš KAŠPÁREK (203 Czech Republic), Hana KUČEROVÁ (203 Czech Republic), Eva ČEŠKOVÁ (203 Czech Republic) and Simona SKOTÁKOVÁ (203 Czech Republic)

Edition

European Neuropsychopharmacology, Amsterdam (The Netherlands), Elsevier, 2006, 0924-977X

Other information

Language

Czech

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.794

RIV identification code

RIV/00216224:14110/06:00017487

Organization unit

Faculty of Medicine

UT WoS

000240771301241

Keywords in English

negative symptoms; schizophrenia; rTMS; treatment

Tags

International impact, Reviewed
Změněno: 19/6/2009 14:34, prof. MUDr. Eva Češková, CSc.

Abstract

V originále

In patients treated with real rTMS before treatment the score of total PANSS was 58.2, positive PANSS 7.7, negative PANSS 21.3 and general PANSS 29.2 and after treatment the score of total PANSS was 45.2, positive PANSS 7.5, negative PANSS 15.5 and general PANSS 22.2. Except of positive PANSS all other PANSS subscales decreased statistically significantly (p<0.05, Wilcoxon Matched Pairs Test). In patients treated with sham rTMS before treatment the score of total PANSS was 64.2, positive PANSS 8.9, negative PANSS 22.1 and general PANSS 33.2 and after treatment the score of total PANSS was 57.0, positive PANSS 8.3, negative PANSS 20.6 and general PANSS 28.1. General and total PANSS subscales decreased only statistically significantly (p<0.05, Wilcoxon Matched Pairs Test), there was no change in negative PANSS. High frequency rTMS applied over the left dorsolateral prefrontal cortex led to a reduction of negative symptoms and may be beneficial as an augmentation option to antipsychotics in the treatment of negative symptoms of schizophrenia.

In English

In patients treated with real rTMS before treatment the score of total PANSS was 58.2, positive PANSS 7.7, negative PANSS 21.3 and general PANSS 29.2 and after treatment the score of total PANSS was 45.2, positive PANSS 7.5, negative PANSS 15.5 and general PANSS 22.2. Except of positive PANSS all other PANSS subscales decreased statistically significantly (p<0.05, Wilcoxon Matched Pairs Test). In patients treated with sham rTMS before treatment the score of total PANSS was 64.2, positive PANSS 8.9, negative PANSS 22.1 and general PANSS 33.2 and after treatment the score of total PANSS was 57.0, positive PANSS 8.3, negative PANSS 20.6 and general PANSS 28.1. General and total PANSS subscales decreased only statistically significantly (p<0.05, Wilcoxon Matched Pairs Test), there was no change in negative PANSS. High frequency rTMS applied over the left dorsolateral prefrontal cortex led to a reduction of negative symptoms and may be beneficial as an augmentation option to antipsychotics in the treatment of negative symptoms of schizophrenia.

Links

MSM0021622404, plan (intention)
Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
NR7986, research and development project
Name: Ovlivnění negativních příznaků schizofrenie pomocí repetitivní transkraniální magnetické stimulace (rTMS) v podmínkách jednoduše slepé, randomizované studie.
Investor: Ministry of Health of the CR