Influencing negative symptoms of schizophrenia with repetitive transcranial magnetic stimulation: a pilot study

PŘIKRYL, Radovan, Libor USTOHAL, Tomáš KAŠPÁREK, Hana KUČEROVÁ, Eva ČEŠKOVÁ and Simona SKOTÁKOVÁ. Influencing negative symptoms of schizophrenia with repetitive transcranial magnetic stimulation: a pilot study. European Neuropsychopharmacology. Amsterdam (The Netherlands): Elsevier, 2006, vol. 16, suppl. 4, p. 444-445. ISSN 0924-977X.

Basic information

• Original name: Influencing negative symptoms of schizophrenia with repetitive transcranial magnetic stimulation: a pilot study
• Name in Czech: Ovlivnění negativních příznaků schizofrenie pomocí rTMS: pilotní studie
• Name (in English): Influencing negative symptoms of schizophrenia with repetitive transcranial magnetic stimulation: a pilot study
• Authors: PŘIKRYL, Radovan (203 Czech Republic, guarantor), Libor USTOHAL (203 Czech Republic), Tomáš KAŠPÁREK (203 Czech Republic), Hana KUČEROVÁ (203 Czech Republic), Eva ČEŠKOVÁ (203 Czech Republic) and Simona SKOTÁKOVÁ (203 Czech Republic).
• Edition: European Neuropsychopharmacology, Amsterdam (The Netherlands), Elsevier, 2006, 0924-977X.

Other information

• Original language: Czech
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 3.794
• RIV identification code: RIV/00216224:14110/06:00017487
• Organization unit: Faculty of Medicine
• UT WoS: 000240771301241
• Keywords in English: negative symptoms; schizophrenia; rTMS; treatment
• Tags: negative symptoms, rTMS, schizophrenia, treatment
• Tags: International impact, Reviewed

Abstract

In patients treated with real rTMS before treatment the score of total PANSS was 58.2, positive PANSS 7.7, negative PANSS 21.3 and general PANSS 29.2 and after treatment the score of total PANSS was 45.2, positive PANSS 7.5, negative PANSS 15.5 and general PANSS 22.2. Except of positive PANSS all other PANSS subscales decreased statistically significantly (p<0.05, Wilcoxon Matched Pairs Test). In patients treated with sham rTMS before treatment the score of total PANSS was 64.2, positive PANSS 8.9, negative PANSS 22.1 and general PANSS 33.2 and after treatment the score of total PANSS was 57.0, positive PANSS 8.3, negative PANSS 20.6 and general PANSS 28.1. General and total PANSS subscales decreased only statistically significantly (p<0.05, Wilcoxon Matched Pairs Test), there was no change in negative PANSS. High frequency rTMS applied over the left dorsolateral prefrontal cortex led to a reduction of negative symptoms and may be beneficial as an augmentation option to antipsychotics in the treatment of negative symptoms of schizophrenia.

Abstract (in English)

In patients treated with real rTMS before treatment the score of total PANSS was 58.2, positive PANSS 7.7, negative PANSS 21.3 and general PANSS 29.2 and after treatment the score of total PANSS was 45.2, positive PANSS 7.5, negative PANSS 15.5 and general PANSS 22.2. Except of positive PANSS all other PANSS subscales decreased statistically significantly (p<0.05, Wilcoxon Matched Pairs Test). In patients treated with sham rTMS before treatment the score of total PANSS was 64.2, positive PANSS 8.9, negative PANSS 22.1 and general PANSS 33.2 and after treatment the score of total PANSS was 57.0, positive PANSS 8.3, negative PANSS 20.6 and general PANSS 28.1. General and total PANSS subscales decreased only statistically significantly (p<0.05, Wilcoxon Matched Pairs Test), there was no change in negative PANSS. High frequency rTMS applied over the left dorsolateral prefrontal cortex led to a reduction of negative symptoms and may be beneficial as an augmentation option to antipsychotics in the treatment of negative symptoms of schizophrenia.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.

• NR7986, research and development project: Name: Ovlivnění negativních příznaků schizofrenie pomocí repetitivní transkraniální magnetické stimulace (rTMS) v podmínkách jednoduše slepé, randomizované studie.

Investor: Ministry of Health of the CR