BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK and Marie NOVÁKOVÁ. Effect of haloperidol on transient outward potassium current in rat ventricular myocytes. European Journal of Pharmacology. Amsterdam, The Netherlands: Elsevier Science B.V., 2006, vol. 550, 1-3, p. 15-23. ISSN 0014-2999.
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Basic information
Original name Effect of haloperidol on transient outward potassium current in rat ventricular myocytes
Name in Czech Vliv haloperidolu na přechodný draslíkový proud z buňky v komorových buňkách potkana
Authors BÉBAROVÁ, Markéta (203 Czech Republic, guarantor), Peter MATEJOVIČ (703 Slovakia), Michal PÁSEK (203 Czech Republic) and Marie NOVÁKOVÁ (203 Czech Republic).
Edition European Journal of Pharmacology, Amsterdam, The Netherlands, Elsevier Science B.V. 2006, 0014-2999.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.522
RIV identification code RIV/00216224:14110/06:00015432
Organization unit Faculty of Medicine
UT WoS 000241790800003
Keywords in English haloperidol; transient outward current; sigma receptors; rat ventricular myocytes; whole-cell pach clamp; quantitative model
Tags haloperidol, quantitative model, rat ventricular myocytes, sigma receptors, transient outward current, whole-cell pach clamp
Tags International impact, Reviewed
Changed by Changed by: doc. MUDr. Markéta Bébarová, Ph.D., učo 15000. Changed: 12/6/2009 15:12.
Abstract
Haloperidol induced a decrease of amplitude and an acceleration of apparent inactivation of transient outward potassium current (Ito), both in a voltage-dependent manner. The averaged inhibition of Ito, evaluated as a change of its time integral, was 23.0 +/- 3.2% at stimulation frequency of 0.1 Hz. As a consequence of slow recovery of Ito from the haloperidol-induced block (time constant 1482 +/- 83 ms), a cumulation of the block up to about 40% appeared at 3.3 Hz.
Abstract (in Czech)
Haloperidol způsobil pokles amplitudy a zrychlení zdálivé inaktivace přechodného draslíkového proudu z buňky (Ito), oboje nezávisle na stimulačním napětí. Průměrná blokáda Ito, hodnocená jako změna integrálu Ito, byla 23.0 +/- 3.2% při stimulační frekvenci 0.1 Hz. V důsledku pomalého návratu Ito z blokády vyvolané haloperidolem (časová konstanta 1482 +/- 83 ms) se při stimulační frekvenci 3.3 Hz objevuje kumulace blokády k asi 40%.
Links
AV0Z20760514, plan (intention)Name: Komplexní dynamické systémy v termodynamice, mechanice tekutin a těles
GA305/04/1385, research and development projectName: Modulační úloha sigma signalizace na elektromechanické vztahy izolovaného kardiomyocytu a srdce
Investor: Czech Science Foundation, Modulatory role of sigma signalling in electromechanical coupling of isolated cardiomyocyte and heart
MSM0021622402, plan (intention)Name: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases
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