Damage to ovarian functions in young women treated with ABVD and BEACOPP chemotherapy for Hodgkin lymfoma

ŠMARDOVÁ, Lenka, Zdeněk KRÁL, Martin HUSER and Igor CRHA. Damage to ovarian functions in young women treated with ABVD and BEACOPP chemotherapy for Hodgkin lymfoma. In Annals of Oncology. 2005. ISSN 0923-7534.

Basic information

• Original name: Damage to ovarian functions in young women treated with ABVD and BEACOPP chemotherapy for Hodgkin lymfoma
• Name in Czech: Poškození ovariálních funkcí u pacientek léčených režimy ABVD a BEACOPP pro Hodgkinský lymfom
• Name (in English): Damage to ovarian functions in young women treated with ABVD and BEACOPP chemotherapy for Hodgkin lymfoma
• Authors: ŠMARDOVÁ, Lenka (203 Czech Republic, guarantor), Zdeněk KRÁL (203 Czech Republic), Martin HUSER (203 Czech Republic) and Igor CRHA (203 Czech Republic).
• Edition: Annals of Oncology, 2005.

Other information

• Original language: Czech
• Type of outcome: Conference abstract
• Field of Study: 30214 Obstetrics and gynaecology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 4.319
• RIV identification code: RIV/00216224:14110/05:00019024
• Organization unit: Faculty of Medicine
• ISSN: 0923-7534
• UT WoS: 000233670100280
• Keywords in English: Hodgkins lymphoma; fertility; ABVD; BEACOPP
• Tags: ABVD, BEACOPP, Fertility, Hodgkins lymphoma
• Tags: International impact, Reviewed

Abstract

Introduction: Depending on the type of the chemotherapy (CT) administered, premature ovarian failure develops in young women, causing clinical symptoms due to the lack of estrogens, and resulting in subsequent sterility. Objectives: Retrospective analysis of the fertility was made in female pts treated with the BEACOPP or ABVD and MOPP(COPP),ABVD CT. Methods: A total of 16 pts underwent the therapy based on the BEACOPP with baseline (n=6) or escal. doses (n=4), or a combination of 4 cycles of the baseline and escal. BEACOPP (n=6). A total of 32 pts were treated with CT in the past, namely using the ABVD (n=25) or the hybrid MOPP(COPP),ABVD alternating regimen (n=7). Results: 5/16 (31 %) of the pts reported oligomenorrhoea or complete amenorrhoea during the BEACOPP. After 6 months from the end of the therapy, half of the pts (n=8) did not menstruate. The menses disappeared during the ABVD or MOPP (COPP)/ABVD in 6/36 (19 %) of the pts. Conclusions: The BEACOPP poses a risk of early menopause and permanent sterility to young patients owing to the presence of several gonadotoxic agents.

Abstract (in English)

Damage to ovarian functions in young women treated with ABVD and BEACOPP chemotherapy for Hodgkin lymfoma.

Links

• NR8469, research and development project: Name: Možnosti ochrany reprodukčních funkcí u žen podstupujících chemoterapii pro hematologickou malignitu