Association of leptin and adiponectin polymorphisms with
endometrial cancer

D 2006

Association of leptin and adiponectin polymorphisms with endometrial cancer

CHOVANEC, Josef, Zuzana DOSTÁLOVÁ, Julie BIENERTOVÁ VAŠKŮ, Anna VAŠKŮ, Atanas-Ivan BELKOV et. al.

Basic information

Original name

Association of leptin and adiponectin polymorphisms with endometrial cancer

Name in Czech

Asociace polymorfismů v genu pro leptin a adiponektin u pacientek s endometriálním karcinomem

Authors

CHOVANEC, Josef (203 Czech Republic), Zuzana DOSTÁLOVÁ (203 Czech Republic), Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, guarantor), Anna VAŠKŮ (203 Czech Republic) and Atanas-Ivan BELKOV (203 Czech Republic)

Edition

Supp 3. London, UK, International Journal of Gynecological Cancer, p. 780-780, 1 pp. 2006

Publisher

Blackwell Publishing

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30214 Obstetrics and gynaecology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/06:00017550

Organization unit

Faculty of Medicine

Keywords in English

Endometrial cancer; obesity; leptin; adiponectin; polymorphism

Abstract

ORIG CZ

V originále

Adiponectin is a recently described protein secreted by adipocytes, whose circulating levels are reduced in conditions related to insulin resistance and hyperinsulinemia. Leptin is small peptide produced by adipocytes and is implicated in a great number of endocrine regulations, whose impairment might result in obesity. The aim of this study was to investigate possible associations of previously described polymorphisms within the leptin (LEP -2548 G/A) and adiponectin gene (T94G) and development of endometrial cancer. Methods: Peripherial blood samples obtained of 16 women with endometrial cancer and 14 healthy controls were evaluated for leptin -2548 G/A and adiponectin T94G polymorphisms. Results: We did not found any significant differences in genotype distributions and allelic frequencies of both examined polymorphims (LEP -2548 G/A: pg=0.13 and Adipo T94G: pg=0.75) in endometrial cancer cases and controls. The endometrial cancer cases differed significantly from the controls in baseline patients characteristics, such as weight (p= < 0.0001), height (p= < 0.0001), LDL cholesterol plasma level (p=0.02) and spontaneous abortion rate (p=0.0006). Conclusions: Our results do not clearly support the hypothesis for leptin and adiponectin polymorphisms involvement in ethiopathogenesis of endometrial cancer. However, as this was a preliminary study, the number of cases in both cohorts might not be sufficient for finding a significant association.

In Czech

Naše studie nepodporuje hypotézu, že definovaná variabilita v genu pro leptin a adiponektin je faktorem velkému účinku v etiopatogenezi endometriálního karcinomu.

Links

MSM 141100002, plan (intention)

Name: Molekulární patofyziologie multigenních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases

Citovat

CHOVANEC, Josef, Zuzana DOSTÁLOVÁ, Julie BIENERTOVÁ VAŠKŮ, Anna VAŠKŮ and Atanas-Ivan BELKOV. Association of leptin and adiponectin polymorphisms with endometrial cancer. In International Journal of Gynecological Cancer. Supp 3. London, UK: Blackwell Publishing, 2006, p. 780-780.

@inproceedings{700795,
   author = {Chovanec, Josef and Dostálová, Zuzana and Bienertová Vašků, Julie and Vašků, Anna and Belkov, AtanasandIvan},
   address = {London, UK},
   booktitle = {International Journal of Gynecological Cancer},
   edition = {Supp 3},
   keywords = {Endometrial cancer; obesity; leptin; adiponectin; polymorphism},
   language = {eng},
   location = {London, UK},
   pages = {780-780},
   publisher = {Blackwell Publishing},
   title = {Association of leptin and adiponectin polymorphisms with endometrial cancer},
   year = {2006}
}

TY  - JOUR
ID  - 700795
AU  - Chovanec, Josef - Dostálová, Zuzana - Bienertová Vašků, Julie - Vašků, Anna - Belkov, Atanas-Ivan
PY  - 2006
TI  - Association of leptin and adiponectin polymorphisms with endometrial cancer
PB  - Blackwell Publishing
CY  - London, UK
KW  - Endometrial cancer
KW  - obesity
KW  - leptin
KW  - adiponectin
KW  - polymorphism
N2  - Adiponectin is a recently described protein secreted by adipocytes, whose circulating levels are reduced in conditions related to insulin resistance and hyperinsulinemia. Leptin is small peptide produced by adipocytes and is implicated in a great number of endocrine regulations, whose impairment might result in obesity. The aim of this study was to investigate possible associations of previously described polymorphisms within the leptin (LEP -2548 G/A) and adiponectin gene (T94G) and development of endometrial cancer. Methods: Peripherial blood samples obtained of 16 women with endometrial cancer and 14 healthy controls were evaluated for leptin -2548 G/A and adiponectin T94G polymorphisms. Results: We did not found any significant differences in genotype distributions and allelic frequencies of both examined polymorphims (LEP -2548 G/A: pg=0.13 and Adipo T94G: pg=0.75) in endometrial cancer cases and controls. The endometrial cancer cases differed significantly from the controls in baseline patients characteristics, such as weight (p= < 0.0001), height (p= < 0.0001), LDL cholesterol plasma level (p=0.02) and spontaneous abortion rate (p=0.0006). Conclusions: Our results do not clearly support the hypothesis for leptin and adiponectin polymorphisms involvement in ethiopathogenesis of endometrial cancer. However, as this was a preliminary study, the number of cases in both cohorts might not be sufficient for finding a significant association.
ER  -

CHOVANEC, Josef, Zuzana DOSTÁLOVÁ, Julie BIENERTOVÁ VAŠKŮ, Anna VAŠKŮ and Atanas-Ivan BELKOV. Association of leptin and adiponectin polymorphisms with endometrial cancer. In \textit{International Journal of Gynecological Cancer}. Supp 3. London, UK: Blackwell Publishing, 2006, p.~780-780.

Detailed Information on Publication Record