DAVID, Marek, Miroslav GABRIEL and Marie KOPECKÁ. Microtubular and actin cytoskeletons and ultrastructural characteristics of the potentially pathogenic basidiomycetous yeast Malassezia pachydermatis. Cell Biology International. England: Elsevier, 2007, vol. 31, No 1, p. 16-23. ISSN 1065-6995.
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Basic information
Original name Microtubular and actin cytoskeletons and ultrastructural characteristics of the potentially pathogenic basidiomycetous yeast Malassezia pachydermatis
Authors DAVID, Marek (203 Czech Republic, belonging to the institution), Miroslav GABRIEL (203 Czech Republic, belonging to the institution) and Marie KOPECKÁ (203 Czech Republic, guarantor, belonging to the institution).
Edition Cell Biology International, England, Elsevier, 2007, 1065-6995.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL publikace URL
Impact factor Impact factor: 1.547
RIV identification code RIV/00216224:14110/07:00020053
Organization unit Faculty of Medicine
UT WoS 000244297300003
Keywords in English actin; basidiomycetous yeasts; cytoskeleton; Malassezia pachydermatis; microtubules; ultrastructure
Tags Actin, basidiomycetous yeast, Cytoskeleton, Malassezia pachydermatis, microtubule, ultrastructure
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Marie Kopecká, CSc., učo 2342. Changed: 17/3/2011 14:23.
Microtubular and actin cytoskeletons were investigated by fluorescence and electron microscopy. Microtubules were detected by indirect immunofluorescence. Cytoplasmic microtubules were detected in interphase and a spindle with astral microtubules was seen in M-phase. The disintegration of cytoplasmic microtubules and migration of the nucleus to the bud before mitosis were characteristic features of the basidiomycetous yeast Malassezia pachydermatis. The visualisation of F-actin structures (patches, cables and cytokinetic rings) by fluorescence microscopy using both monoclonal anti-actin antibody and rhodamine-phalloidin failed, but actin was detected by electron microscopy with immunogold labelling. Clusters of gold particles indicating actin structures were detected at the plasma membrane of cells with unique cortical ultrastructural features characteristic of the genus Malassezia. A possible association of these with the actin cytoskeleton is suggested.
GA310/03/1195, research and development projectName: Cytoskelet jako terčová struktura pro studium účinku antifungálních látek u patogenních kvasinek
Investor: Czech Science Foundation
GA310/06/0605, research and development projectName: Lidské patogenní houby : cytoskelet jako potenciální terč inhibice morfogeneze.
Investor: Czech Science Foundation, Human pathogenic fungi: the cytoskeleton as a potential target of inhibition of
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