Comparison of the effects of cannabidiol in two mouse models of depression

PISTOVČÁKOVÁ, Jana, Alexandra ŠULCOVÁ and Brian LEONARD. Comparison of the effects of cannabidiol in two mouse models of depression. In Collegium Internationale Neuro-Psychopharmacologicum - Book of Abstracts. Tallinn, Estonia: CINP, 2006, p. 56.

Basic information

• Original name: Comparison of the effects of cannabidiol in two mouse models of depression
• Name in Czech: Srovnání účinků kanabidiolu ve dvou myších modelech deprese
• Authors: PISTOVČÁKOVÁ, Jana, Alexandra ŠULCOVÁ and Brian LEONARD.
• Edition: Tallinn, Estonia, Collegium Internationale Neuro-Psychopharmacologicum - Book of Abstracts, p. 56-56, 2006.
• Publisher: CINP

Other information

• Original language: English
• Type of outcome: Proceedings paper
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Estonia
• Confidentiality degree: is not subject to a state or trade secret
• Organization unit: Faculty of Medicine
• Keywords in English: cannabidiol; animal model of depression; olfactory bulbectomy; social defeat; mice
• Tags: animal model of depression, cannabidiol, mice, olfactory bulbectomy, social defeat
• Tags: International impact, Reviewed

Abstract

Cannabidiol referred as a potential anxiolytic and antidepressant agent was tested in the mouse models of social defeat and the bilateral olfactory bulbectomy for its antidepressant activity. The behavioural data received in both behavioural tests can support more likely cannabidiol potential anxiolytic than antidepressant-like activity. Cannabidiol significantly disinhibited the suppressed phagocytosis of leukocytes in the OB mice, which resembles effects of the antidepressants in this animal models.

Abstract (in Czech)

Canabidiol, u kterého se předpokládá anxiolytický a antidepresivní účinek, byl testován ve dvou myších modelech deprese - modele sociální porážky a bilaterální olfaktorické bulbektomie. Získaná behaviorální data nepotvrdily antidepresivní aktivitu testované látky, a svědčí spíše pro anxiolytický účinek kanabidiolu.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.