Detailed Information on Publication Record
2006
Comparison of the effects of cannabidiol in two mouse models of depression
PISTOVČÁKOVÁ, Jana, Alexandra ŠULCOVÁ and Brian LEONARDBasic information
Original name
Comparison of the effects of cannabidiol in two mouse models of depression
Name in Czech
Srovnání účinků kanabidiolu ve dvou myších modelech deprese
Authors
PISTOVČÁKOVÁ, Jana, Alexandra ŠULCOVÁ and Brian LEONARD
Edition
Tallinn, Estonia, Collegium Internationale Neuro-Psychopharmacologicum - Book of Abstracts, p. 56-56, 2006
Publisher
CINP
Other information
Language
English
Type of outcome
Stať ve sborníku
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
Estonia
Confidentiality degree
není předmětem státního či obchodního tajemství
Organization unit
Faculty of Medicine
Keywords in English
cannabidiol; animal model of depression; olfactory bulbectomy; social defeat; mice
Tags
International impact, Reviewed
Změněno: 12/12/2006 11:59, MUDr. Jana Pistovčáková, Ph.D.
V originále
Cannabidiol referred as a potential anxiolytic and antidepressant agent was tested in the mouse models of social defeat and the bilateral olfactory bulbectomy for its antidepressant activity. The behavioural data received in both behavioural tests can support more likely cannabidiol potential anxiolytic than antidepressant-like activity. Cannabidiol significantly disinhibited the suppressed phagocytosis of leukocytes in the OB mice, which resembles effects of the antidepressants in this animal models.
In Czech
Canabidiol, u kterého se předpokládá anxiolytický a antidepresivní účinek, byl testován ve dvou myších modelech deprese - modele sociální porážky a bilaterální olfaktorické bulbektomie. Získaná behaviorální data nepotvrdily antidepresivní aktivitu testované látky, a svědčí spíše pro anxiolytický účinek kanabidiolu.
Links
| MSM0021622404, plan (intention) |
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