J 2006

Antidepressant-like cannabidiol effects on exploratory behaviour in mice

PISTOVČÁKOVÁ, Jana and Alexandra ŠULCOVÁ

Basic information

Original name

Antidepressant-like cannabidiol effects on exploratory behaviour in mice

Name in Czech

Antidepresivní účinky kanabidiolu na explorační chování u myší

Authors

PISTOVČÁKOVÁ, Jana (703 Slovakia, guarantor) and Alexandra ŠULCOVÁ (203 Czech Republic)

Edition

Homeostasis in Health and Diseases, Milano, Italy, CIANS Homeostasis, 2006, 0960-7560

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Italy

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/06:00017756

Organization unit

Faculty of Medicine

Keywords in English

cannabidiol; mice; antidepressant

Tags

International impact, Reviewed
Změněno: 12/12/2006 12:01, MUDr. Jana Pistovčáková, Ph.D.

Abstract

V originále

The aim of the experiment was to analyse the behavioural effects of citalopram, valproate and cannabidiol, and verify the hypothesis that CBD, similarly to citalopram and valproate, would reduce behavioural responses to social stress induced by repeated social conflict. The data suggest an antidepressant-like effect of CBD in mice defeated by an aggressive conspecific partner. These data are in agreement with human studies (Ashton et al., 2005; Crippa et al., 2004) and contribute to a number of reports on the multitude of diverse actions of cannabidiol that might be of medical use.

In Czech

Cílem práce bylo testování behaviorálních účinků kanabidiolu a jejich srovnání s účinky citalopramu a valproátu v modelů sociálního stresu u myší. Výsledky naznačují možné antidepresivní účinky kanabidiolu.

Links

MSM0021622404, plan (intention)
Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.