Behavioural and immune effects of cannabidiol in a mouse model of bilateral olfactory bulbectomy

PISTOVČÁKOVÁ, Jana, Alexandra ŠULCOVÁ, John KELLY and Brian LEONARD. Behavioural and immune effects of cannabidiol in a mouse model of bilateral olfactory bulbectomy. The International Journal of Neuropsychopharmacology. Cambridge, U.K.: Cambridge University Press, 2006, vol. 9, No 12, p. 778. ISSN 1461-1457.

Basic information

Original name

Behavioural and immune effects of cannabidiol in a mouse model of bilateral olfactory bulbectomy

Name in Czech

Behaviorální a imunitní účinky kanabidiolu v myším modelu bilaterální olfaktorické bulbektomie

Authors

PISTOVČÁKOVÁ, Jana (703 Slovakia, guarantor), Alexandra ŠULCOVÁ (203 Czech Republic), John KELLY (372 Ireland) and Brian LEONARD (372 Ireland)

Edition

The International Journal of Neuropsychopharmacology, Cambridge, U.K. Cambridge University Press, 2006, 1461-1457

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 5.184

RIV identification code

RIV/00216224:14110/06:00017758

Organization unit

Faculty of Medicine

Keywords in English

cannabidiol; mice; depression; olfactory bulbectomy

Tags

cannabidiol, Depression, mice, olfactory bulbectomy

Tags

International impact, Reviewed

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Abstract

V originále

The study tested an antidepressant effect of cannabidiol (CBD) in olfactory bulbectomized (OB) mice, a well-established animal model of depression resembling behavioural, immune and endocrine changes. CBD did not show antidepressant behavioural properties in this animal model. This can discussed in relation to our previous results in social defeat mouse model, where CBD appeared to elicit anxiolytic activity. Reversal of the suppressed leukocyte phagocytosis in the OB mice by CBD correlates with the stimulatory effect of cannabinoids reffered in the literature.

In Czech

Sledovány byly behaviorální a imunitní účinky kanabidiolu v myším modelu deprese - bilaterální olfaktorické bulbektomie. Behaviorální antidepresivní účinky kanabidiolu nebyly jednoznačně prokázány. Kanabidiol normalizoval potlačenou leukocytární fagocytózu v použitém zvířecím modelu deprese.

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Links

MSM 141100001, plan (intention)	Name: Plasticita řídících systémů centrálního nervového systému a možnosti jejího ovlivnění
MSM0021622404, plan (intention)	Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.