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@article{704213,
author = {Dvořák, Petr and Hampl, Aleš and Dvořáková, Dana},
article_number = {12},
keywords = {stem cells},
language = {eng},
issn = {0014-5793},
journal = {FEBS Letters},
title = {Fibroblast growth factor signaling in embryonic and cancer stem cells},
volume = {580},
year = {2006}
}
TY - JOUR
ID - 704213
AU - Dvořák, Petr - Hampl, Aleš - Dvořáková, Dana
PY - 2006
TI - Fibroblast growth factor signaling in embryonic and cancer stem cells
JF - FEBS Letters
VL - 580
IS - 12
SP - 2869-2874
EP - 2869-2874
SN - 00145793
KW - stem cells
N2 - Cancer stem cells are cancer cells that originate from the transformation of normal stem cells. The most important property of any stem cell is the ability to self-renew. Through this property, there are striking parallels between normal stem cells and cancer stem cells. Both cell types share various markers of "stemness". In particular, normal stem cells and cancer stem cells utilize similar molecular mechanisms to drive self-renewal, and similar signaling pathways may induce their differentiation. The fibroblast growth factor 2 (FGF-2) pathway is one of the most significant regulators of human embryonic stem cell (hESC) self-renewal and cancer cell tumorigenesis. Here we summarize recent data on the effects of FGF-2 and its receptors on hESCs and leukemic stem/progenitor cells. Also, we discuss the similarities of these findings with stem cell renewal and differentiation phenotypes.
ER -
DVOŘÁK, Petr, Aleš HAMPL and Dana DVOŘÁKOVÁ. Fibroblast growth factor signaling in embryonic and cancer stem cells. \textit{FEBS Letters}. 2006, vol.~580, No~12, p.~2869-2874. ISSN~0014-5793.
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