MDMA pre-treatment cross-sensitizes to methamphetamine stimulatory effects in mice

KUČEROVÁ, Jana, Leoš LANDA, Karel ŠLAIS and Alexandra ŠULCOVÁ. MDMA pre-treatment cross-sensitizes to methamphetamine stimulatory effects in mice. European Neuropsychopharmacology. Amsterdam (The Netherlands): Elsevier, 2006, vol. 2006, No 16, p. 513-513. ISSN 0924-977X.

Basic information

Original name

MDMA pre-treatment cross-sensitizes to methamphetamine stimulatory effects in mice

Name in Czech

Premedikace MDMA zkříženě sensitizuje myši ke stimulačním účinkům metamfetaminu

Authors

KUČEROVÁ, Jana, Leoš LANDA, Karel ŠLAIS and Alexandra ŠULCOVÁ

Edition

European Neuropsychopharmacology, Amsterdam (The Netherlands), Elsevier, 2006, 0924-977X

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

France

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.794

Organization unit

Faculty of Medicine

UT WoS

000240771302110

Keywords in English

behavioural sensitization; mice; ecstasy; methamphetamine

Tags

behavioural sensitization, ecstasy, methamphetamine, mice

Tags

International impact, Reviewed

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Abstract

V originále

Various psychostimulant drugs induce after their repeated administration a significant increase in behavioural responses, phenomenon known as behavioural sensitization. In our recent studies we demonstrated development of this phenomenon after repeated administration of methamphetamine (Met) and its expression following Met challenge dose after the withdrawal lasting 6 days. Furthermore, pretreatment with CB1 receptor agonist methanandamide elicited behavioural cross-sensitization to Met stimulatory effects. By analogy, we decided to test a possible cross-sensitization to Met with another widely abused substance - MDMA (ecstasy), and vice versa with Met repeated pretreatment to MDMA effects.

In Czech

Opakované podání různých psychostimulancií vyvolává behaviorální sensitizaci (zvýšený účinek). V našich nedávných studiích jsme již prokázali existenci rozvoje (po opakovaném podání) i exprese (provokující dávka po periodě abstinence) behaviorální sensitizace k metamfetaminu. Rovněž premedikace agonistou CB1 receptoru metanandamidem vedla ke vzniku zkřížené sensitizace k metamfetaminu. Analogicky jsme se rozhodli otestovat možný vznik zkřížené sensitizace k extázi (MDMA) po premedikaci metanandamidem.

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Links

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.