Gender differences in effects of MDMA, cannabinoid agonist and their combinations in mice

KUČEROVÁ, Jana, Leoš LANDA, Karel ŠLAIS and Alexandra ŠULCOVÁ. Gender differences in effects of MDMA, cannabinoid agonist and their combinations in mice (Gender differences in effectS of MDMA, cannabinoid agonist and their combinations in mice.). European Neuropsychopharmacology. Amsterdam (The Netherlands): Elsevier, 2006, vol. 2006, No 16, p. 512-512. ISSN 0924-977X.

Basic information

Original name

Gender differences in effects of MDMA, cannabinoid agonist and their combinations in mice

Name in Czech

Mezipohlavní rozdíly v účincích extáze, kanabinoidního agonisty a jejich kombinací u myší

Authors

KUČEROVÁ, Jana, Leoš LANDA, Karel ŠLAIS and Alexandra ŠULCOVÁ

Edition

European Neuropsychopharmacology, Amsterdam (The Netherlands), Elsevier, 2006, 0924-977X

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

France

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.794

Organization unit

Faculty of Medicine

UT WoS

000240771302109

Keywords in English

gender differences; behavioural sensitization; mice; ecstasy; methanandamide

Tags

behavioural sensitization, ecstasy, gender differences, methanandamide, mice

Tags

International impact, Reviewed

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Abstract

V originále

The outcome of the present study showed higher susceptibility of female mice to acute MDMA administration, however the behavioural sensitization development (during the repeated treatment) and expression (caused by the challenge dose given after the drug withdrawal) were confirmed only in males. The pretreatment with cannabinoid CB1 receptor agonist led to sensitization to MDMA stimulatory effects in all animals.

In Czech

Prokázali jsme mnohočetné mezipohlavní rozdíly v behaviorální sensitizaci myší populace ke stimulačním účinkům extáze. U obou pohlaví se rovněž projevila zkřížená sensitizace k extázi po opakované premedikaci agonistou CB1 receptorů metanandamidem.

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Links

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.