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@article{704404,
author = {Tillinger, Andrej and Bruderová, V. and Kubovčáková, Lucie and Zeman, Michal and Kopáček, J. and Nováková, Marie and Květňanský, Richard and Križanová, Olga},
article_location = {Bratislava},
article_number = {4},
keywords = {PNMT; cardiac atria; cardiac ventricles; hypoxia; cold stress; renin},
language = {eng},
issn = {0231-5882},
journal = {General Physiology and Biophysics},
title = {Gene expression of the phenylethanolamine N-methyltransferase is differently modulated in cardiac atria and ventricles},
volume = {25},
year = {2006}
}
TY - JOUR
ID - 704404
AU - Tillinger, Andrej - Bruderová, V. - Kubovčáková, Lucie - Zeman, Michal - Kopáček, J. - Nováková, Marie - Květňanský, Richard - Križanová, Olga
PY - 2006
TI - Gene expression of the phenylethanolamine N-methyltransferase is differently modulated in cardiac atria and ventricles
JF - General Physiology and Biophysics
VL - 25
IS - 4
SP - 355-364
EP - 355-364
PB - Slovak Academy of Sciences
SN - 02315882
KW - PNMT
KW - cardiac atria
KW - cardiac ventricles
KW - hypoxia
KW - cold stress
KW - renin
N2 - Phenylethanolamine N-methyltransferase (PNMT) is a final enzyme in catecholamine synthesizing cascade that converts noradrenaline to adrenaline. Although most profuse in adrenal medulla, PNMT is expressed also in the heart, particularly in cardiac atria and ventricles. In atria, the PNMT mRNA is much more abundant compared to ventricles. In this work we aimed to find out, whether there is difference in modulation of the PNMT gene expression in cardiac atria and ventricles. We used three methodological approaches - cold as a model of mild stress, hypoxia as a model of cardiac ischemic injury and transgenic rats with incorporated mouse renin gene [TGR (mREN-2)27], to determine involvement of renin-angiotensin pathway in the PNMT gene expression. We have found that PNMT gene expression was modulated differently in cardiac atria and ventricles. In atria PNMT mRNA levels were increased by hypoxia, while cold stress decreased PNMT mRNA levels. In ventricles, no significant changes were observed by cold or hypoxia. On the other hand, angiotensin II elevated PNMT gene expression in ventricles, but not in atria. These results suggest that PNMT gene expression is modulated differently in cardiac atria and ventricles and might result in different physiological consequences.
ER -
TILLINGER, Andrej, V. BRUDEROVÁ, Lucie KUBOVČÁKOVÁ, Michal ZEMAN, J. KOPÁČEK, Marie NOVÁKOVÁ, Richard KVĚTŇANSKÝ and Olga KRIŽANOVÁ. Gene expression of the phenylethanolamine N-methyltransferase is differently modulated in cardiac atria and ventricles. \textit{General Physiology and Biophysics}. Bratislava: Slovak Academy of Sciences, 2006, vol.~25, No~4, p.~355-364. ISSN~0231-5882.
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