ŘIHÁČEK, Ivan, Miroslav SOUČEK and Petr FRÁŇA. THE SMOOTHNESS INDEX OF BETAXOLOL HYDROCHLORIDE AND METOPROLOLE IN PATIENTS WITH NEWLY DIAGNOSED HYPERTENSION. Journal of Hypertension. 2006, vol. 24, suppl 6, p. S316, 1 pp. ISSN 0952-1178.
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Basic information
Original name THE SMOOTHNESS INDEX OF BETAXOLOL HYDROCHLORIDE AND METOPROLOLE IN PATIENTS WITH NEWLY DIAGNOSED HYPERTENSION.
Name in Czech Smoothness index betaxolol hydrochloridu a metoprololu u pacientů s čerstvě zjištěnou hypertenzí
Authors ŘIHÁČEK, Ivan (203 Czech Republic, guarantor), Miroslav SOUČEK (203 Czech Republic) and Petr FRÁŇA (203 Czech Republic).
Edition Journal of Hypertension, 2006, 0952-1178.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/06:00017793
Organization unit Faculty of Medicine
UT WoS 000242774002154
Keywords in English hypertension;blood pressure monitoring;beta-blockers.
Tags beta-blockers., blood pressure monitoring, Hypertension
Tags International impact, Reviewed
Changed by Changed by: MUDr. Ivan Řiháček, Ph.D., učo 2313. Changed: 8/12/2006 13:00.
Abstract
BP measurement using 24-hour ambulatory blood pressure monitoring (SpaceLabs 90207) according to the ESH criteria. We evaluated 60 patients in two groups before and after the 3months of treatment with 20mg betaxolol hydrochloride or 200mg slow-release metoprolole. The smoothness index was obtained by calculating the average BP values for each hour of the 24-hour monitoring period, both before and during treatment. From these, all hourly changes in BP induced by treatment were obtained, and the average of these hourly values was divided by its standard deviation. Results: SI of metoprolole was for systolic BP 1,25 +- 0,88 SD, [95% CI, 0,35 to 1,55] and for diastolic BP 1,43 +- 1,14 SD, [95% CI, 1,02 to 1,84]. SI of betaxolole hydrochloride was for systolic BP 1,00 +- 0,65 SD, [95% CI, 0,77 to 1,23] and for diastolic BP 1,19 +- 0,92 SD, [95% CI, 0,86 to 1,52]. 95% CI = 95% confidence interval. Man Whitney U test comparison of SI of both drugs was for systolic BP, P = 0,2728, for diastolic BP, P = 0,4317. Conclusion: Both drugs had SI equal or higher than 1, reflecting a homogeneous effect throughout 24-hour. No statistically significant differences in SI were observed between treatments. Acknowledgements: The study was supported by grant of Ministry of Education, Youth and Sports of Czech Republic, No. MSM0021622402.
Abstract (in Czech)
Měření TK pomocí 24h ambulantního monitorování TK (SpaceLabs 90207) podle kritérií ESH. Vyšetřili jsme 60 pacientů ve dvou souborech před a po 3měsíční léčbě 20mg betaxolol hydrochloridu a 200 mg retardovaného metoprololu. Smoothness index byl vypočten z průměrných hodinových hodnot TK při 24hodinovém monitorování před a po léčbě. Všechny průměrné hodinové změny TK po léčbě byly děleny jejich směrodatnou odchylkou. Výsledky: SI metoprololu pro STK 1,25 +- 0,88 SD, [95% CI, 0,35 - 1,55] a pro DTK 1,43 +- 1,14 SD, [95% CI, 1,02 - 1,84]. SI betaxolol hydrochloridu pro STK 1,00 +- 0,65 SD, [95% CI, 0,77 - 1,23] a pro DTK 1,19 +- 0,92 SD, [95% CI, 0,86 - 1,52]. 95% CI = 95% interval spolehlivosti. Srovnáním SI obou léků Man Whitney U testem: pro STK, P = 0,2728, pro DTK, P = 0,4317, pro obě hodnoty rozdíly statisticky nevýznamné. Závěr: oba léky mají SI vyšší než 1 a tím zjištěnu dobrou 24hodinovou účinnost. Mezi léky nebyly zjištěny statisticky významné rozdíly. Poděkování: práce byla podporována grantem MŠMT české republiky číslo: MSM0021622402.
Links
MSM0021622402, plan (intention)Name: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases
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