J 2006

A comparison of the trough-peak ratio of cardio-selective beta-blockers in patients with newly diagnosed hypertension.

SOUČEK, Miroslav, Ivan ŘIHÁČEK and Petr FRÁŇA

Basic information

Original name

A comparison of the trough-peak ratio of cardio-selective beta-blockers in patients with newly diagnosed hypertension.

Name in Czech

Srovnání trough-peak poměru kardioselektivních beta-blokátorů u pacientů s čerstvě zjištěnou hypertenzí.

Name (in English)

A comparison of the trough-peak ratio of cardio-selective beta-blockers in patients with newly diagnosed hypertension.

Authors

SOUČEK, Miroslav (203 Czech Republic), Ivan ŘIHÁČEK (203 Czech Republic, guarantor) and Petr FRÁŇA (203 Czech Republic)

Edition

Blood pressure monitoring, Londýn, Lippincott, Williams and Wilkins, 2006, 1359-5237

Other information

Language

Czech

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.424

RIV identification code

RIV/00216224:14110/06:00017798

Organization unit

Faculty of Medicine

Keywords in English

blood pressure monitoring;hypertension;trough-to-peak ratio;beta-blockers.

Tags

International impact, Reviewed
Změněno: 8/12/2006 15:03, MUDr. Ivan Řiháček, Ph.D.

Abstract

V originále

The drug can be administered once a day, if the tough-to-peak ratio (T/P) exceeds 50-66%. The mean T/P of betaxolol hydrochloride was calculated 72,84 +- 33,32% (95% CI, 60,40-85,28%) for systolic BP and 71,57 +-29,35% (95% CI, 60,62-82,53%) for diastolic BP. The mean T/P of metoprolol tartrate was calculated 70,59 +- 31,66% (95% CI, 58,76-82,41%) fo systolic BP and 66,95 +- 31,60% (95% CI, 55,15-78,75%) for diastolic BP. 95% CI - 95% confidence interval. Conclusion: The T/P ratio determined for betaxolol hydrochloride and metoprolol tartrate is higher than 66%. The ratio garatees a satisfactory 24-h effect of both the above mentioned drugs.

In English

The drug can be administered once a day, if the tough-to-peak ratio (T/P) exceeds 50-66%. The mean T/P of betaxolol hydrochloride was calculated 72,84 +- 33,32% (95% CI, 60,40-85,28%) for systolic BP and 71,57 +-29,35% (95% CI, 60,62-82,53%) for diastolic BP. The mean T/P of metoprolol tartrate was calculated 70,59 +- 31,66% (95% CI, 58,76-82,41%) fo systolic BP and 66,95 +- 31,60% (95% CI, 55,15-78,75%) for diastolic BP. 95% CI - 95% confidence interval. Conclusion: The T/P ratio determined for betaxolol hydrochloride and metoprolol tartrate is higher than 66%. The ratio garatees a satisfactory 24-h effect of both the above mentioned drugs.

Links

MSM0021622402, plan (intention)
Name: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases