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@article{704426,
author = {Eyer, Luděk and Pantůček, Roman and Zdráhal, Zbyněk and Konečná, Hana and Kašpárek, Petr and Růžičková, Vladislava and Hernychová, Lenka and Preisler, Jan and Doškař, Jiří},
article_location = {Weinheim},
article_number = {1},
keywords = {staphylococcus bacteriophage; proteome; Myoviridae; Staphylococcus aureus; phage therapy},
language = {eng},
issn = {1615-9853},
journal = {Proteomics},
title = {Structural protein analysis of the polyvalent staphylococcal bacteriophage 812},
url = {http://www3.interscience.wiley.com/cgi-bin/abstract/113510179/ABSTRACT},
volume = {7},
year = {2007}
}
TY - JOUR
ID - 704426
AU - Eyer, Luděk - Pantůček, Roman - Zdráhal, Zbyněk - Konečná, Hana - Kašpárek, Petr - Růžičková, Vladislava - Hernychová, Lenka - Preisler, Jan - Doškař, Jiří
PY - 2007
TI - Structural protein analysis of the polyvalent staphylococcal bacteriophage 812
JF - Proteomics
VL - 7
IS - 1
SP - 64-72
EP - 64-72
PB - Wiley-VCH
SN - 16159853
KW - staphylococcus bacteriophage
KW - proteome
KW - Myoviridae
KW - Staphylococcus aureus
KW - phage therapy
UR - http://www3.interscience.wiley.com/cgi-bin/abstract/113510179/ABSTRACT
N2 - Phage 812 is a polyvalent phage with a very broad host range in the genus Staphylococcus, which makes it a suitable candidate for phage therapy of staphylococcal infections. This proteomic study, combining the results of both 1-DE and 2-DE followed by PMF, led to the identification of 24 virion proteins. Twenty new proteins, not yet identified by proteome analysis of closely related staphylococcal phages K and G1 were identified using this approach. Fifteen proteins were assigned unambiguously to the head-tail genome module; the remaining nine proteins are encoded by genes of the left or right arms of the phage genome. As expected, the most abundant proteins in the electrophoretic patterns are the major capsid protein, the major tail sheath protein and proteins identical to ORF 50 and ORF 95 of phage K, although their function is only putative. Identification of these 20 new proteins contributes substantially to a detailed characterization of phage virions, knowledge of which is necessary for rational phage therapy
ER -
EYER, Luděk, Roman PANTŮČEK, Zbyněk ZDRÁHAL, Hana KONEČNÁ, Petr KAŠPÁREK, Vladislava RŮŽIČKOVÁ, Lenka HERNYCHOVÁ, Jan PREISLER and Jiří DOŠKAŘ. Structural protein analysis of the polyvalent staphylococcal bacteriophage 812. \textit{Proteomics}. Weinheim: Wiley-VCH, 2007, vol.~7, No~1, p.~64-72. ISSN~1615-9853.
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