An experimental animal model of spinal root compression- an analysis of morphological changes

JANČÁLEK, Radim and Petr DUBOVÝ. An experimental animal model of spinal root compression- an analysis of morphological changes. Experimental Brain Research. Springer Berlin / Heidelberg: Springer Berlin / Heidelberg, 2006, vol. 179, No 1, p. 111-119. ISSN 0014-4819.

Basic information

• Original name: An experimental animal model of spinal root compression- an analysis of morphological changes
• Name in Czech: Experimentální model komprese spinálních kořenů
• Authors: JANČÁLEK, Radim (203 Czech Republic, belonging to the institution) and Petr DUBOVÝ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Experimental Brain Research, Springer Berlin / Heidelberg, Springer Berlin / Heidelberg, 2006, 0014-4819.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Germany
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 1.959
• RIV identification code: RIV/00216224:14110/06:00016141
• Organization unit: Faculty of Medicine
• UT WoS: 000245976700010
• Keywords in English: Spinal root - Compression - Morphometry - Treatment
• Tags: International impact, Reviewed

Abstract

The treatment of radicular pain is mainly empirical because there are only few experimental studies dealing with morphological changes during compression radiculopathy. The goal of the study was to investigate changes in the morphology of myelinated axons during spinal root compression and the inXuence of decompression in a new rat model. The number of myelinated axons and their diameter were measured at 1, 2, 5, and 8 weeks during compression of the dorsal spinal root. The same approach was applied for 1-week compression followed by decompression for 1 or 2 weeks and compression for 5 weeks followed by 3-week decompression. A decrease in the number of myelinated axons (particularly those of large diameters) occurred after compression for 1 week. Continued compression for up to 8 weeks resulted in centripetal increase in the number of myelinated axons and the persistence of a small fraction of large myelinated axons at the site of compression. After that time, a decreased number of axons and a reduced fraction of large myelinated axons occurred again. Decompression after 1-week compression caused a rapid increase in the number of both small and large myelinated axons within the spinal root including the site of compression.

Abstract (in Czech)

Léčba radikulární bolestije založena zejména na empirických znalostech, protože dosud máme jen velmi málo experimentálních studií, které se zabývají morfologickými změnami po kompresi spinálních kořenů. Cílem studie bylo zjistit morfologické změny, které nastávají v průběhu kompresní radikulopatie na experimentálním modelu po kompresi a dekompresi.

Links

• GA309/03/1199, research and development project: Name: Změny v satelitních gliových buňkách a jejich extracelulární matrix po axotomii - podmínky pro tvorbu sympatických kolaterál ve spinálních gangliích ?

Investor: Czech Science Foundation

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.