An experimental animal model of spinal root compression- an analysis of morphological changes

JANČÁLEK, Radim and Petr DUBOVÝ. An experimental animal model of spinal root compression- an analysis of morphological changes. Experimental Brain Research. Springer Berlin / Heidelberg: Springer Berlin / Heidelberg, 2006, vol. 179, No 1, p. 111-119. ISSN 0014-4819.

Basic information

Original name

An experimental animal model of spinal root compression- an analysis of morphological changes

Name in Czech

Experimentální model komprese spinálních kořenů

Authors

JANČÁLEK, Radim (203 Czech Republic, belonging to the institution) and Petr DUBOVÝ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Experimental Brain Research, Springer Berlin / Heidelberg, Springer Berlin / Heidelberg, 2006, 0014-4819

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.959

RIV identification code

RIV/00216224:14110/06:00016141

Organization unit

Faculty of Medicine

UT WoS

000245976700010

Keywords in English

Spinal root - Compression - Morphometry - Treatment

Tags

International impact, Reviewed

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Abstract

V originále

The treatment of radicular pain is mainly empirical because there are only few experimental studies dealing with morphological changes during compression radiculopathy. The goal of the study was to investigate changes in the morphology of myelinated axons during spinal root compression and the inXuence of decompression in a new rat model. The number of myelinated axons and their diameter were measured at 1, 2, 5, and 8 weeks during compression of the dorsal spinal root. The same approach was applied for 1-week compression followed by decompression for 1 or 2 weeks and compression for 5 weeks followed by 3-week decompression. A decrease in the number of myelinated axons (particularly those of large diameters) occurred after compression for 1 week. Continued compression for up to 8 weeks resulted in centripetal increase in the number of myelinated axons and the persistence of a small fraction of large myelinated axons at the site of compression. After that time, a decreased number of axons and a reduced fraction of large myelinated axons occurred again. Decompression after 1-week compression caused a rapid increase in the number of both small and large myelinated axons within the spinal root including the site of compression.

In Czech

Léčba radikulární bolestije založena zejména na empirických znalostech, protože dosud máme jen velmi málo experimentálních studií, které se zabývají morfologickými změnami po kompresi spinálních kořenů. Cílem studie bylo zjistit morfologické změny, které nastávají v průběhu kompresní radikulopatie na experimentálním modelu po kompresi a dekompresi.

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Links

GA309/03/1199, research and development project	Name: Změny v satelitních gliových buňkách a jejich extracelulární matrix po axotomii - podmínky pro tvorbu sympatických kolaterál ve spinálních gangliích ? Investor: Czech Science Foundation
MSM0021622404, plan (intention)	Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.