ŠIMKOVÁ, Andrea, Martina PEČÍNKOVÁ, Barbora BÍMOVÁ and Peter MIKULÍČEK. The associations between MHC genes and metazoan parasites in the fish populations living under the different level of environmental pollution. In The 35th Annual Congress of the Parasitological Society of Southern Africa, Windhoek (Namibia), Book of Abstracts. Windhoek, Namibie: Department of Biology, University of Namibia, Windhoek, Namibia, 2006, p. 23.
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Basic information
Original name The associations between MHC genes and metazoan parasites in the fish populations living under the different level of environmental pollution
Name in Czech Vztah mezi MHC geny a rybími mnohobuněčnými parazity v odlišných environmentálních podmínkách
Authors ŠIMKOVÁ, Andrea (203 Czech Republic, guarantor), Martina PEČÍNKOVÁ (203 Czech Republic), Barbora BÍMOVÁ (203 Czech Republic) and Peter MIKULÍČEK (703 Slovakia).
Edition Windhoek, Namibie, The 35th Annual Congress of the Parasitological Society of Southern Africa, Windhoek (Namibia), Book of Abstracts, p. 23-23, 2006.
Publisher Department of Biology, University of Namibia, Windhoek, Namibia
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 10600 1.6 Biological sciences
Country of publisher Namibia
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14310/06:00016154
Organization unit Faculty of Science
Keywords in English MHC genes;fish;parasite
Tags FISH, MHC genes, parasite
Tags International impact
Changed by Changed by: prof. RNDr. Andrea Vetešníková Šimková, PhD., učo 24570. Changed: 8/1/2007 19:38.
Abstract
The major histocompatibility complex (MHC) represents a group of genes of the highly polymorphic loci encoding the proteins that bind a peptide fragments derived from the foreign antigens and stimulate an immune response. The specific role of MHC as a mediator of the adaptive immune response suggests that the MHC profile could reflect the effects of environmental changes connected with chemical pollution as well as the indirect parasite-mediated selection. However, until now MHC variation has not been often used in the pollutant assays. In our study we tested whether the immunogenetic profiles measured by nucleotide and amino-acid substitutions in MHC class IIB (DAB genes) predominantly in peptide-binding regions vary between fish populations living under conditions of different environmental stress and parasite pressure. In the freshwater fish gudgeon, Gobio gobio, three populations collected from the localities differing by the environmental pollution (heavy metals and persistent organic pollutants) were studied. Fish were investigated for all metazoan parasites and the representatives of Monogenea, Digenea, Cestoda and Acanthocephala were recorded. The differences in presence or absence of the metazoan parasite species were observed as well as the parasite intensity infection was different when comparing three localities. Moreover, the different composition of parasite communities was observed concerning the proportions of specialist and generalist parasites. Even several MHC haplotypes were shared between populations, the specific alleles (or the specific nucleotide or amino-acid motives within alleles) were observed in each locality. The relationships between parasitism and MHC diversity in the association with different level of environmental pollution were analyzed and discussed.
Abstract (in Czech)
The major histocompatibility complex (MHC) represents a group of genes of the highly polymorphic loci encoding the proteins that bind a peptide fragments derived from the foreign antigens and stimulate an immune response. The specific role of MHC as a mediator of the adaptive immune response suggests that the MHC profile could reflect the effects of environmental changes connected with chemical pollution as well as the indirect parasite-mediated selection. However, until now MHC variation has not been often used in the pollutant assays. In our study we tested whether the immunogenetic profiles measured by nucleotide and amino-acid substitutions in MHC class IIB (DAB genes) predominantly in peptide-binding regions vary between fish populations living under conditions of different environmental stress and parasite pressure. In the freshwater fish gudgeon, Gobio gobio, three populations collected from the localities differing by the environmental pollution (heavy metals and persistent organic pollutants) were studied. Fish were investigated for all metazoan parasites and the representatives of Monogenea, Digenea, Cestoda and Acanthocephala were recorded. The differences in presence or absence of the metazoan parasite species were observed as well as the parasite intensity infection was different when comparing three localities. Moreover, the different composition of parasite communities was observed concerning the proportions of specialist and generalist parasites. Even several MHC haplotypes were shared between populations, the specific alleles (or the specific nucleotide or amino-acid motives within alleles) were observed in each locality. The relationships between parasitism and MHC diversity in the association with different level of environmental pollution were analyzed and discussed.
Links
GA524/04/1128, research and development projectName: MHC třída IIB genů evropských kaprovitých ryb: jejich genetická variabilita a evoluce ve vztahu k životní strategii hostitelů a parazitismu
Investor: Czech Science Foundation, MHC class IIB genes of European cyprinid fish: their genetic variability and evolution in relation to the host life-history traits and parasitism
MSM0021622416, plan (intention)Name: Diverzita biotických společenstev a populací: kauzální analýza variability v prostoru a čase
Investor: Ministry of Education, Youth and Sports of the CR, Diversity of Biotic Communities and Populations: Causal Analysis of variation in space and time
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