Detailed Information on Publication Record
2006
Cisplatin electrochemical biosensor
PETRLOVÁ, Jitka, David POTĚŠIL, Josef ZEHNÁLEK, Berd SURES, Vojtěch ADAM et. al.Basic information
Original name
Cisplatin electrochemical biosensor
Name in Czech
Elektrochemický biosenzor cisplatiny
Authors
PETRLOVÁ, Jitka (203 Czech Republic), David POTĚŠIL (203 Czech Republic), Josef ZEHNÁLEK (203 Czech Republic), Berd SURES (276 Germany), Vojtěch ADAM (203 Czech Republic), Libuše TRNKOVÁ (203 Czech Republic, guarantor) and René KIZEK (203 Czech Republic)
Edition
Electrochim. Acta, 2006, 0013-4686
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10405 Electrochemistry
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.955
RIV identification code
RIV/00216224:14310/06:00016155
Organization unit
Faculty of Science
UT WoS
000239253900023
Keywords in English
Cisplatin; electrochemical biosensor
Změněno: 18/12/2006 12:08, Ing. Radka Mikelová, Ph.D.
V originále
Platinum complexes play an important role in the chemotherapy of various tumour diseases. The aim of this paper was to investigate if a metallothionein (MT) modified hanging mercury drop electrode can be applied as a cisplatin electrochemical biosensor. The modification of the mercury electrode surface by MT and the determination of cisplatin were performed by adsorptive transfer stripping technique and differential pulse voltammetry. The detection limit (3 S/N) of cisplatin ([Pt-II(NH3)(2)Cl-2](0)) calculated from the decrease of CdT peak was about 2.5 pmol in 5 mu l (0.5 mu M) at the interaction time of 400 s. Moreover, we tested the influence of human blood serum as a complex biological matrix on the way of determination of cisplatin. On the basis of the obtained results we estimated that we are able to determine tens of picomoles of cisplatin (5 mu l drop) in the presence of human blood serum.
In Czech
Elektrochemický biosenzor cisplatiny
Links
| GP525/04/P132, research and development project |
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